{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:21:26Z","timestamp":1788182486741,"version":"build-2803163510"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) is a discrete autoimmune, neuroinflammatory demyelinating disease with a broad clinical spectrum caused by antibodies against MOG proteins on myelin and oligodendrocytes. It is now recognized as a separate disease from multiple sclerosis and neuromyelitis optica spectrum disorder (AQP4-IgG + NMOSD). A 40-year-old female presented with a history of fever, acute onset visual impairment and painful extra ocular movements of left eye, ataxia, giddiness, bitemporal headache, and urinary retention. Cerebrospinal fluid evaluation showed lymphocytic pleiocytosis, serum anti-MOG antibodies were positive (1:100), and magnetic resonance imaging (MRI) showed multiple lesions involving the diencephalon, brainstem and periventricular white matter and conus medullaris. The patient was started on a 5 day pulse dose of injection METHYLPREDNISOLONE 1 g followed by a gradually tapering dose of oral prednisolone for 1 month. Patient recovered completely with no residual disease and was followed up for 1 year. Repeat serum MOG antibodies were negative and MRI showed complete resolution of both brain and spinal lesions. MOGAD is an emerging autoimmune neuroinflammatory disease that is not only distinct in its presentation, but also in response to disease modifying therapies with a better prognosis and lower morbidity than the other demyelinating diseases. A high suspicion for its clinical phenotypes and radiological peculiarities must be held for avoiding misdiagnosis and for early management.<\/jats:p>","DOI":"10.4103\/aam.aam_343_25","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T17:00:43Z","timestamp":1757955643000},"page":"1306-1308","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["An Emerging Autoimmune Neuroinflammatory Disease: Myelin Oligodendrocyte Glycoprotein Antibody Disease"],"prefix":"10.4103","volume":"25","author":[{"given":"Satbir Kaur","family":"Malik","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atharvan Sharma","family":"Mangalapalli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemanjali","family":"Avuthu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"R1-20260831","doi-asserted-by":"crossref","first-page":"11059","DOI":"10.1073\/pnas.1833158100","article-title":"The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis","volume":"100","author":"Clements","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R2-20260831","doi-asserted-by":"crossref","first-page":"9446","DOI":"10.1073\/pnas.1133443100","article-title":"Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein","volume":"100","author":"Breithaupt","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R3-20260831","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ncl.2023.06.009","article-title":"Updates in NMOSD and MOGAD diagnosis and treatment: A tale of two central nervous system autoimmune inflammatory disorders","volume":"42","author":"Cacciaguerra","year":"2024","journal-title":"Neurol Clin"},{"key":"R4-20260831","doi-asserted-by":"crossref","first-page":"885218","DOI":"10.3389\/fneur.2022.885218","article-title":"Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD): A review of clinical and MRI features, diagnosis, and management","volume":"13","author":"Sechi","year":"2022","journal-title":"Front Neurol"},{"key":"R5-20260831","doi-asserted-by":"crossref","first-page":"1594960","DOI":"10.3389\/fimmu.2025.1594960","article-title":"Biomarkers for diagnosis and prognosis of myelin oligodendrocyte glycoprotein antibody-associated disease \u2013 Review article","volume":"16","author":"Sapana","year":"2025","journal-title":"Front Immunol"},{"key":"R6-20260831","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S1474-4422(22)00431-8","article-title":"Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria","volume":"22","author":"Banwell","year":"2023","journal-title":"Lancet Neurol"}],"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_343_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:01:19Z","timestamp":1788181279000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_343_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,15]]},"references-count":6,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/aam.aam_343_25","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,15]]},"assertion":[{"value":"2025-07-15","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}