{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:32:27Z","timestamp":1786649547292,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of the study was to assess the prevalence of osteoporosis in patients with monoclonal gammopathy of undetermined significance (MGUS) and to determine the associated factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>we conducted a case\u2013control study, between January 2019 and April 2019, including patients with MGUS and age- and sex-matched healthy controls (one patient\/three controls). For all participants, demographic and clinical data were collected as results of bone mineral density by two-photon X-ray absorptiometry at the lumbar spine and femoral neck.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In our series, we included 120 participants: 30 patients with MGUS and 90 healthy controls. In the MGUS carrier group, the mean age was 66.26 \u00b1 8.61 years. The mean monoclonal peak was 11.57 g\/L. Densitometric osteoporosis was noted in 12 (40%) patients with MGUS versus 17 (18.9%) in the control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.021). In addition, only one patient with MGUS had a vertebral fracture. On multivariate analysis, associated factors with osteoporosis in the MGUS group were age (odds ratio [OR] = 1.14; confidence interval [CI] [1.03\u20131.26];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05) and previous fracture (OR = 3.03; CI [1.22\u201315.06];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study suggests an increased risk of osteoporosis in patients with MGUS.<\/jats:p>\n                  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