{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T12:31:53Z","timestamp":1787142713774,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Red cell exchange (RCE) is the removal of a patient\u2019s diseased red cells and replacing them with normal donor red cells either manually or using an automated cell separator. It is the treatment of choice in patients with sickle cell disease (SCD) presenting with acute stroke and severe acute chest syndrome with hypoxia. However, its use is limited because of the need for sophisticated equipment, specialized staff, and high cost of procedure. A total of 10 automated red blood cell exchanges were performed from January 2016 to December 2023 in patients who were in the age group 2 year\u201335 year with mean age 18.6 years. All the procedures were performed on Com.Tec (version 04.03.07) which has inbuilt software program. Among these 10 patients, 7 were male and 3 were female patients. Out of 10 patients, 9 were of SCD and one was of poisoning. In our study, 1 out of 10 patients had alloantibody Anti E, so antigen negative, phenotype matched, crossmatch compatible blood was given. The targeted and final fraction of red cell remaining (FCR) values were kept at &lt;30% which was achieved in all cases. RCE is a safe and effective therapeutic treatment procedure with minimal or no side effects when performed at the right time by trained staff.<\/jats:p>","DOI":"10.4103\/aam.aam_365_25","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T13:00:38Z","timestamp":1767186038000},"page":"S60-S63","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Role of Automated Red Cell Exchange in Sickle Cell Anemia and Poisoning"],"prefix":"10.4103","volume":"25","author":[{"given":"Harkiran","family":"Arora","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine, Max Superspeciality Hospital, Shalimar Bagh, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Khetarpal","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Artemis Hospital, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Syal","sequence":"additional","affiliation":[{"name":"Department of IHBT, Gian Sagar Medical College and Hospital, Jhansla, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"R1-20260819","first-page":"646","article-title":"Logistics, risks, and benefits of automated red blood cell exchange for patients with sickle cell disease","author":"Kelly","year":"2023","journal-title":"Hematology Am Soc Hematol Educ Program 2023"},{"key":"R2-20260819","doi-asserted-by":"crossref","first-page":"767","DOI":"10.3390\/jcm10040767","article-title":"Automated red cell exchange in the management of sickle cell disease","volume":"10","author":"Tsitsikas","year":"2021","journal-title":"J Clin Med"},{"key":"R3-20260819","first-page":"C28","article-title":"Study of twenty one cases of red cell exchange in a tertiary care hospital in Southern India","volume":"10","author":"Daniel","year":"2016","journal-title":"J Clin Diagn Res"},{"key":"R4-20260819","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4103\/gjtm.gjtm_13_21","article-title":"Blood cell exchange in sickle cell disease: A single center experience","volume":"6","author":"Chowdhry","year":"2021","journal-title":"Glob J Trans Med"},{"key":"R5-20260819","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1159\/000504144","article-title":"Red blood cells: Exchange, transfuse, or deplete","volume":"46","author":"Stussi","year":"2019","journal-title":"Transfus Med Hemother"},{"key":"R6-20260819","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/jca.21705","article-title":"Guidelines on the use of therapeutic apheresis in clinical practice \u2013 Evidence-based approach from the writing committee of the American society for apheresis: The eighth special issue","volume":"34","author":"Padmanabhan","year":"2019","journal-title":"J Clin Apher"},{"key":"R7-20260819","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/bjh.14346","article-title":"Guidelines on red cell transfusion in sickle cell disease. 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