{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:23:55Z","timestamp":1783013035122,"version":"3.54.6"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"Abstract<\/jats:title>\n \n Introduction:<\/jats:title>\n Oral squamous cell carcinoma (OSCC) is a very frequently occurring cancer type. A salivary biomarker-based noninvasive diagnostic technique helps as promising method in the early detection of cancer. This research was done to assess salivary biomarkers\u2019 diagnostic value for early OSCC identification.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n One hundred and twenty people participated in a hospital-based case\u2013control study, 60 of whom were OSCC patients with histological confirmation and 60 of whom were healthy controls. Biomarkers such as interleukin-6 (IL-6), IL-8, tumor necrosis factor-alpha, IL-1\u03b2, matrix metalloproteinase-9 (MMP-9), CD44, soluble CD44, CYFRA 21-1, and lactate dehydrogenase were detected using enzyme-linked immunosorbent assay on unstimulated saliva samples. SPSS version 25.0 was used for statistical analysis. Receiver operating characteristic curve analysis was used to assess diagnostic ability and make intergroup comparisons.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n When compared to controls, all salivary biomarkers were considerably higher in OSCC patients (\n P<\/jats:italic>\n < 0.001). Among the individual markers, IL-8 had the best diagnostic accuracy (area under the curve [AUC] =0.92), followed by MMP-9 and CYFRA 21-1. Biomarkers showed strong positive associations with OSCC, suggesting biological interdependence. With an AUC of 0.96, sensitivity of 93.3%, and specificity of 91.7%, the combined biomarker panel showed outstanding diagnostic performance.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Salivary biomarkers have greater assurance for noninvasively and accurately identifying OSCC at a very early stage. The use of multiple biomarkers together can lead to better diagnosis and could help in early screening and achieve good clinical results.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/aam.aam_372_26","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:58:34Z","timestamp":1783011514000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Oral Squamous Cell Cancer Early Detection Using Salivary Biomarkers"],"prefix":"10.4103","author":[{"given":"Mounika","family":"Yeladandi","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Radiology, Mallareddy Dental College for Women, Malla Reddy Vishwavidyapeeth, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada Mohamed Ahmed","family":"Suliman","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Dentistry, King Faisal University, Al Ahsa Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti Goyal","family":"Rastogi","sequence":"additional","affiliation":[{"name":"Dental Surgeon, 2908-208, Enfield place, Mississauga, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasmita","family":"Behera","sequence":"additional","affiliation":[{"name":"Intern, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Fareed","family":"Mohsin","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diagnostic Sciences, College of Dentistry, Qassim University, Buraydah, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazargi","family":"Mahabob","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, King Faisal University, Al Hofuf, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzammil Moin","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Mujoo","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Babaji","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Sharavathi Dental College, Shivamogga, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,2]]},"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/aam.aam_372_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:58:34Z","timestamp":1783011514000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.4103\/aam.aam_372_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/aam.aam_372_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,2]]},"assertion":[{"value":"2026-04-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}