{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:29:25Z","timestamp":1793795365436,"version":"4.6.1"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mixed endometrial carcinoma (MEC) is a rare entity, representing only a small fraction of endometrial cancers. It is characterized by the presence of two or more distinct histological patterns, with at least one being a high-grade type such as serous or clear cell carcinoma. We present a 61-year-old postmenopausal woman who presented with abnormal uterine bleeding, intermittent lower abdominal pain, and mild pelvic discomfort for 2 months. Ultrasound revealed a thickened, irregular endometrium with a heterogeneous mass. Endometrial biopsy and immunohistochemistry confirmed the presence of mixed endometrial carcinoma. Subsequently, the patient underwent hysterectomy, and on gross, the endometrial cavity was showing a friable, irregular growth with papillary excrescences infiltrating into the myometrium. On microscopy, the coexistence of endometrioid and serous components was established, confirming the diagnosis.<\/jats:p>","DOI":"10.4103\/aam.aam_377_26","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:02:09Z","timestamp":1783422129000},"page":"S735-S738","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Unmasking Mixed Endometrial Carcinoma: A Case Report of Diagnostic Complexity"],"prefix":"10.4103","volume":"25","author":[{"given":"Neha","family":"Yadav","sequence":"first","affiliation":[{"name":"Department of Pathology, Uttar Pradesh University of Medical Sciences, Etawah, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay Kumar","family":"Kannaujia","sequence":"additional","affiliation":[{"name":"Department of Pathology, Uttar Pradesh University of Medical Sciences, Etawah, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpi","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Uttar Pradesh University of Medical Sciences, Etawah, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabana Andleeb","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Pathology, Uttar Pradesh University of Medical Sciences, Etawah, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasdeep","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Pathology, Uttar Pradesh University of Medical Sciences, Etawah, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"R1-20261104","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/S0140-6736(22)00323-3","article-title":"Endometrial cancer","volume":"399","author":"Crosbie","year":"2022","journal-title":"Lancet"},{"key":"R2-20261104","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.humpath.2004.02.007","article-title":"Prognostic parameters of endometrial carcinoma","volume":"35","author":"Prat","year":"2004","journal-title":"Hum Pathol"},{"key":"R3-20261104","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/0090-8258(92)90130-B","article-title":"Uterine papillary serous carcinoma: A study on 108 cases with emphasis on the prognostic significance of associated endometrioid carcinoma, absence of invasion, and concomitant ovarian carcinoma","volume":"47","author":"Carcangiu","year":"1992","journal-title":"Gynecol Oncol"},{"key":"R4-20261104","doi-asserted-by":"crossref","first-page":"6373","DOI":"10.3390\/jcm12196373","article-title":"Mixed endometrial epithelial carcinoma: Epidemiology, treatment and survival rates-a 10-year retrospective cohort study from a single institution","volume":"12","author":"Pappa","year":"2023","journal-title":"J Clin Med"},{"issue":"Suppl 1","key":"R6-20261104","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1097\/PGP.0000000000000512","article-title":"Issues in the differential diagnosis of uterine low-grade endometrioid carcinoma, including mixed endometrial carcinomas: Recommendations from the international society of gynecological pathologists","volume":"38","author":"Rabban","year":"2019","journal-title":"Int J Gynecol Pathol"},{"key":"R7-20261104","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1097\/PAS.0b013e31827f576a","article-title":"Poor interobserver reproducibility in the diagnosis of high-grade endometrial carcinoma","volume":"37","author":"Gilks","year":"2013","journal-title":"Am J Surg Pathol"},{"key":"R8-20261104","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1177\/1933719110368433","article-title":"Minor serous and clear cell components adversely affect prognosis in \"mixed-type\" endometrial carcinomas: A clinicopathologic study of 36 stage-I cases","volume":"17","author":"Quddus","year":"2010","journal-title":"Reprod Sci"},{"key":"R9-20261104","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nature12113","article-title":"Integrated genomic characterization of endometrial carcinoma","volume":"497","author":"Kandoth","year":"2013","journal-title":"Nature"}],"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_377_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:04:45Z","timestamp":1793793885000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_377_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":8,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/aam.aam_377_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]},"assertion":[{"value":"2026-04-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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