{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:59:21Z","timestamp":1790067561095,"version":"4.0.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Isotonic fluids like 0.9% normal saline (NS) are recommended for maintenance intravenous fluid (mIVF) therapy in children. However, concerns exist regarding hyperchloremia and its associated complications, particularly in younger children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of the study was to evaluate the clinical and metabolic effects of 0.9% NS as mIVF in noncritically ill pediatric patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This longitudinal study included 80 children aged 1 month to 13 years admitted to a tertiary care center, who received 0.9% NS as mIVF for at least 50% of a 24-h period. Baseline and 48-h clinical and biochemical parameters were recorded and compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      After 48 h, there was a significant decrease in heart rate, respiratory rate, blood urea, and serum creatinine, and a significant increase in blood pressure, serum sodium, potassium, and chloride (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Hyperchloremia was observed in 7.5% of children, all aged &lt;5 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>0.9% NS may lead to significant clinical and metabolic changes, particularly hyperchloremia in younger children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aam.aam_414_25","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T18:00:17Z","timestamp":1764352817000},"page":"1650-1655","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The Clinical and Metabolic Derangements after Using 0.9% Normal Saline as Maintenance Intravenous Fluid in Children"],"prefix":"10.4103","volume":"25","author":[{"given":"Amal Jainy","family":"James","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Amala Institute of 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