{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:44:11Z","timestamp":1782992651034,"version":"3.54.5"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Crigler\u2013Najjar syndrome (CNN) type I is a rare autosomal recessive disorder caused by complete deficiency of uridine 5\u2032-diphosphate glucuronosyltransferase 1A1, leading to severe unconjugated hyperbilirubinemia and a high risk of kernicterus. We describe the case of a 7-year-old girl with CNN type I and kernicterus who presented with fever and breakthrough seizures during an upper respiratory infection, with severe neurodevelopmental impairment, including spastic quadriplegic cerebral palsy, epilepsy, global developmental delay, and failure to thrive. This case highlights the devastating, irreversible neurological sequelae of untreated neonatal hyperbilirubinemia and emphasizes the importance of early diagnosis and aggressive management.<\/jats:p>","DOI":"10.4103\/aam.aam_427_26","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:00:15Z","timestamp":1782990015000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Crigler-Najjar Syndrome (Type 1) \u2013 A Case Report and Review of Literature"],"prefix":"10.4103","author":[{"given":"Elham Nazari","family":"Fard","sequence":"first","affiliation":[{"name":"Department of Pediatrics, RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Al","family":"Yasari","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa","family":"Sharafeldin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rand Nedal","family":"Fatayerji","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim Duraid","family":"Al-Obaidi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muneeb","family":"Mazhar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf Abouelseoud","family":"Noureldin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhranshu Sekhar","family":"Kar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajani","family":"Dube","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B K Manjunatha","family":"Goud","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,1]]},"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/aam.aam_427_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:00:15Z","timestamp":1782990015000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.4103\/aam.aam_427_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/aam.aam_427_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"assertion":[{"value":"2026-04-14","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}