{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:59:19Z","timestamp":1790067559759,"version":"4.0.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Serum resistin has been implicated in atherosclerosis and vascular smooth muscle dysfunction through inflammatory pathways, making it a potential biomarker for cardiovascular risk. Comparative data in diabetic patients with acute vascular events are limited. This study evaluates serum resistin and high-sensitivity C-reactive protein (hs-CRP) levels in type 2 diabetes mellitus (T2DM) with acute myocardial infarction (AMI) or acute ischemic stroke (AIS) to explore their association with vascular complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      A cross-sectional, hospital-based study was conducted among T2DM patients presenting with AMI or AIS. Serum resistin, hs-CRP, glycated hemoglobin (HbA1c), lipid profile, and body mass index (BMI) were evaluated, and their associations with vascular events were statistically analyzed, considering\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05 as statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean serum resistin was significantly higher in the diabetes mellitus (DM) with AMI group (23.21 \u00b1 5.65 ng\/ml;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) compared to controls (13.30 \u00b1 2.94 ng\/ml) but not in the DM with AIS group (19.90 \u00b1 5.46 ng\/ml;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.215). hs-CRP was significantly elevated in both DM with AMI and AIS groups (3.43 \u00b1 0.70 mg\/l and 3.43 \u00b1 1.01 mg\/l, respectively) compared to controls (2.43 \u00b1 0.62 mg\/l; both\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Positive correlations were observed between these biomarkers and conventional risk factors, including HbA1c, BMI, and low-density lipoprotein cholesterol.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Elevated serum resistin (notably in AMI) and hs-CRP (in both AMI and AIS) in T2DM patients highlight a strong association between inflammation and acute vascular events. These biomarkers may serve as accessible tools for early risk stratification and targeted preventive strategies in high-risk diabetic populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aam.aam_428_25","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:00:29Z","timestamp":1769083229000},"page":"1595-1601","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Serum Resistin and High-sensitivity C-reactive Protein as Independent Predictors of Vascular Complications in Type 2 Diabetes Mellitus: A Cross-sectional Observational Study at a Tertiary Care Center"],"prefix":"10.4103","volume":"25","author":[{"given":"B. J.","family":"Subhashchandra","sequence":"first","affiliation":[{"name":"Department of General Medicine, JSS Medical College and Hospital, JSSAHER, Mysuru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of General Medicine, JSS Medical College and Hospital, JSSAHER, Mysuru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskar Prakash","family":"Gowd","sequence":"additional","affiliation":[{"name":"Department of General Medicine, MAPIMS, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiju Sam","family":"Jacob","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Sree Narayana Institute of Medical Sciences, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"R2-20260922","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cca.2020.11.010","article-title":"Resistin: Potential biomarker and therapeutic target in 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