{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:29:04Z","timestamp":1786649344383,"version":"build-2736575974"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Despite guideline-directed selection, cardiac resynchronization therapy (CRT) fails to achieve meaningful clinical or echocardiographic improvement in 20%\u201340% of patients. In nonischemic cardiomyopathy, occult myocardial inflammation may represent an under-recognized determinant of CRT nonresponse. This study evaluated the role of positron emission tomography (PET)-derived myocardial uptake in predicting CRT response and arrhythmic burden.<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n The objective of this study was to assess whether myocardial inflammation detected by 18F-fluorodeoxyglucose PET-computed tomography (18F-FDG PET-CT) influences response to CRT and device-detected arrhythmias in patients with nonischemic cardiomyopathy.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n In this prospective, single-center observational case\u2013control study, 236 patients evaluated for CRT were screened, of whom 23 patients with nonischemic cardiomyopathy fulfilling Class I indications underwent 18F-FDG PET-CT within 12 weeks of CRT -pacemaker\/CRT -defibrillator (CRT-P\/CRT-D) implantation. CRT response was defined by \u226510% absolute improvement in left ventricular ejection fraction (LVEF), \u22651 New York Heart Association functional class improvement, or \u226515% improvement in functional surrogate parameters. Patients were categorized as PET-positive or PET-negative based on myocardial FDG uptake. Receiver-operating characteristic (ROC) analysis was used to determine the predictive value of PET uptake.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Among 23 patients, 14 (61%) were classified as CRT responders and 9 (39%) as nonresponders. Responders were significantly younger and had a lower prevalence of atrial high-rate events and clinical congestion. Mean PET uptake was significantly lower in responders compared with nonresponders (2.1 \u00b1 1.8 vs. 10.1 \u00b1 3.2;\n P<\/jats:italic>\n < 0.001). A PET uptake threshold \u22655 units was present in 86% of nonresponders but only 11% of responders (\n P<\/jats:italic>\n < 0.001). PET uptake demonstrated excellent predictive accuracy for CRT response (area under the curve = 0.86), with a sensitivity of 86% and specificity of 78%.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n PET-CT provides significant incremental value beyond conventional electrical and echocardiographic criteria and may serve as a useful adjunct in refining patient selection for CRT.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/aam.aam_44_26","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:00:06Z","timestamp":1775800806000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Role of 18F-fluorodeoxyglucose Positron Emission Tomography-computed Tomography in Predicting Response to Cardiac Resynchronization Therapy in Nonischemic Cardiomyopathy"],"prefix":"10.4103","author":[{"given":"Ashutosh","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Cardiology, Kamineni Institute of Medical Sciences, Hyderabad, Telengana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhawani","family":"Goru","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Malla Reddy Institute of Medical Sciences, Hyderabad, Telengana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panduranga","family":"Patwari","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Care Hospitals, HiTech City, Hyderabad, Telengana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, AIG Hospitals, Hyderabad, Telengana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4,9]]},"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_44_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:52:43Z","timestamp":1786647163000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_44_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,9]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/aam.aam_44_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,9]]},"assertion":[{"value":"2026-01-16","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}