{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:34:58Z","timestamp":1787578498651,"version":"build-2736575974"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"Abstract<\/jats:title>\n \n Introduction:<\/jats:title>\n Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition with both smoking and nonsmoking etiologies. Data comparing clinicoradiological characteristics and bronchodilator response (BDR) between smokers and nonsmokers remain limited, mainly in low- and middle-income countries. Therefore, this investigation aimed to compare these parameters among smokers and nonsmokers with COPD.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n This hospital-based, prospective, comparative, cross-sectional study was conducted at a tertiary care center over 18 months. A total of 80 COPD patients (40 smokers and 40 nonsmokers) were enrolled. Baseline clinical, radiological, and spirometric data were recorded, and follow-up assessment was performed at 3 months. Pulmonary function testing was conducted according to the American Thoracic Society\/European Respiratory Society guidelines. Data were analyzed by utilizing SPSS, with\n P<\/jats:italic>\n < 0.05 considered statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Baseline characteristics have been comparable among groups, except for gender distribution (\n P<\/jats:italic>\n < 0.001). Smokers had significantly higher respiratory rate and lower oxygen saturation (\n P<\/jats:italic>\n < 0.05). Hyperinflation was more common among smokers (\n P<\/jats:italic>\n < 0.05), whereas nonsmokers showed greater radiological improvement. Although baseline pulmonary function was similar, nonsmokers demonstrated significantly greater improvement in forced expiratory volume in 1 sec and higher bronchodilator responsiveness (\n P<\/jats:italic>\n < 0.05). Symptom burden was enhanced in both groups without a significant intergroup difference (\n P<\/jats:italic>\n > 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Smokers with COPD exhibit greater physiological impairment and structural lung changes, whereas nonsmokers demonstrate better BDR and functional recovery. These findings highlight COPD heterogeneity and the need for phenotype-based management strategies\n .<\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/aam.aam_482_26","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:11:47Z","timestamp":1787577107000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A Prospective Comparative Study of Clinicoradiological Characteristics, Pulmonary Function, and Bronchodilator Response in Smokers and Nonsmokers with Chronic Obstructive Pulmonary Disease"],"prefix":"10.4103","author":[{"given":"K.","family":"Jisna","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Jereen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Arthi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George Roshan Prasanth","family":"Durairaj","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhinesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,25]]},"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_482_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:11:48Z","timestamp":1787577108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_482_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/aam.aam_482_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,25]]},"assertion":[{"value":"2026-04-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-24","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}