{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:27:50Z","timestamp":1786728470304,"version":"build-2736575974"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"Abstract<\/jats:title>\n \n Introduction:<\/jats:title>\n Worldwide, diabetic nephropathy (DN) is a major contributor to end-stage renal disease. Early detection remains challenging, necessitating the identification of novel biomarkers. Platelet activation and size, as indicated by Mean Platelet Volume (MPV), have emerged as a potential marker for diabetic microvascular complications. To evaluate the association between MPV and DN in type 2 diabetes mellitus (T2DM) patients and assess its utility as an early diagnostic marker.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n One hundred and twenty-five T2DM patients aged >40 years were included in a cross-sectional study at a tertiary care center. Participants were categorized into nephropathy (\n n<\/jats:italic>\n = 73) and non-nephropathy (\n n<\/jats:italic>\n = 52) groups based on estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR). MPV was measured using automated hematology analyzers. Statistical analyses included correlation studies, receiver operating characteristic (ROC) curve analysis, and logistic regression.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The nephropathy group demonstrated significantly elevated MPV levels compared to the nonnephropathy group (12.30 \u00b1 1.55 vs. 9.61 \u00b1 1.2 fl,\n P<\/jats:italic>\n < 0.001). MPV showed strong correlations with diabetes duration (rs = 0.543,\n P<\/jats:italic>\n < 0.001), eGFR (rs = \u22120.581,\n P<\/jats:italic>\n < 0.001), and UACR (rs = 0.585,\n P<\/jats:italic>\n < 0.001). ROC analysis revealed an optimal MPV cutoff of 11.04 fL for predicting nephropathy with 85.6% accuracy, 89.0% sensitivity, and 80.8% specificity. Each unit increase in MPV was associated with a 3.65-fold increased risk of nephropathy (odds ratio: 3.650, 95% confidence interval: 2.320\u20135.750,\n P<\/jats:italic>\n < 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n MPV represents a simple, cost-effective biomarker for early detection of DN in T2DM patients. Its incorporation into routine clinical assessment could facilitate timely intervention and improve patient outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/aam.aam_520_25","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:00:33Z","timestamp":1769083233000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Mean Platelet Volume as a Novel Biomarker for Early Detection of Diabetic Nephropathy in Type 2 Diabetes Mellitus: A Cross-sectional Study in a Tertiary Care Center in Jharkhand"],"prefix":"10.4103","author":[{"given":"Khusboo","family":"Kumari","sequence":"first","affiliation":[{"name":"Department of Clinical Hematology, KGMU, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shishir Kumar","family":"Mahto","sequence":"additional","affiliation":[{"name":"Department of Physiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Saroj","sequence":"additional","affiliation":[{"name":"Blood Centre, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vimlesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Physiology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujeet","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. D. Arif","family":"Tauheed","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushma","family":"Kumari","sequence":"additional","affiliation":[{"name":"Blood Centre, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit","family":"Dungdung","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,21]]},"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_520_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:27:26Z","timestamp":1786724846000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_520_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/aam.aam_520_25","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,21]]},"assertion":[{"value":"2025-09-13","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}