{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T06:13:53Z","timestamp":1784787233940,"version":"3.55.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dermatomyositis (DM) is a type of inflammatory myopathy of unknown origin that is marked by weakness in the proximal muscles, skin manifestations, and involvement of other systems. The existence of anti-transcription intermediary factor-1 gamma (anti-TIF1 \u03b3) antibodies identifies a specific subgroup linked to cancer, interstitial lung disease (ILD), and unusual clinical presentations. We present a rare and complex case of DM positive for anti-TIF1 \u03b3 antibodies, which manifested as inflammatory myopathy, ILD, neuropathy, symptoms of sicca syndrome, and gastrointestinal involvement in an elderly woman with various other health issues. A 69-year-old female patient with progressive weakness in her proximal muscles, joint pain, difficulty swallowing, dry eyes and mouth, a persistent cough, and weight loss. Laboratory tests showed anemia, raised inflammatory markers, a positive antinuclear antibody test, (RF) Rheumatoid Factor, (Anti-CCP) Anti-Cyclic Citrullinated Peptide, and a strongly positive anti-TIF1 \u03b3 antibody result. A magnetic resonance imaging of her bilateral thighs indicated signs of inflammatory myositis, while a high-resolution computed tomography (CT) scan of the chest revealed an ILD pattern that was non-(UIP) Usual Interstitial Pneumonia, suggesting the presence of follicular bronchiolitis. Nerve conduction tests indicated sensory-motor axonal neuropathy. A positron emission tomography-CT scan revealed no signs of metabolically active cancer. The patient was diagnosed with anti-TIF1 \u03b3-positive DM featuring ILD and multiple system involvement and began immunosuppressive treatment. This case underscores the diagnostic challenges associated with anti-TIF1 \u03b3 DM, particularly in the absence of cancer, and highlights the necessity of a multidisciplinary care approach. Early recognition of antibody-specific manifestations is crucial for proper assessment, outcome prediction, and treatment.<\/jats:p>","DOI":"10.4103\/aam.aam_547_26","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T06:00:13Z","timestamp":1784786413000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Anti-transcription Intermediary Factor-1 Gamma Antibody-positive Dermatomyositis with Interstitial Lung Disease and Multisystem Involvement: A Case Report"],"prefix":"10.4103","author":[{"given":"Md.","family":"Amjad","sequence":"first","affiliation":[{"name":"Department of General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilesh","family":"Jagdale","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Kamble","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,23]]},"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/aam.aam_547_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T06:00:14Z","timestamp":1784786414000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.4103\/aam.aam_547_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/aam.aam_547_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]},"assertion":[{"value":"2026-05-02","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-15","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}