{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:36:58Z","timestamp":1786117018155,"version":"build-2736575974"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Studies have shown a relation between Vitamin B12 (B12) and cognitive impairment in Alzheimer\u2019s disease (AD). However, B12 levels do not indicate the severity of the disease. High homocysteine-induced neuroinflammation has been related to the pathogenesis of AD.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n This study aimed to determine the correlation of Vitamin B12 and serum homocysteine with the cognitive status of AD patients.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n AD patients (\n n<\/jats:italic>\n = 25) and healthy controls (\n n<\/jats:italic>\n = 25) were recruited for this study. The revised criteria for diagnosis and staging of AD were used for the diagnosis of AD. Clinical history, laboratory investigations (B12, homocysteine, lipid profile, C-reactive protein, and serum creatinine), and Mini-Mental Status Examination (MMSE) were done. Based on MMSE score, AD patients were subdivided into four groups. All statistical analyses were done on IBM SPSSv26.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n In AD patients, B12 was lower (221.3 \u00b1 54.5 vs. 396.6 \u00b1 88.4 pg\/ml,\n P<\/jats:italic>\n = 0.00), serum homocysteine was higher (15.2 \u00b1 4.6 vs. 11.7 \u00b1 2.3 \u00b5mol\/L, P = 0.00), and C-reactive protein was higher (0.95 \u00b1 \u00b1 0.39 vs. 0.69 \u00b1 0.12 mg\/dl,\n P<\/jats:italic>\n = 0.00). Among the four AD groups, we observed a gradual increase in the serum homocysteine levels with a decline in the cognitive status (lower MMSE score) (\n F<\/jats:italic>\n = 13.32,\n P<\/jats:italic>\n = 0.00). MMSE score had a statistically significant correlation with homocysteine (\u03c1 = \u22120.85,\n P<\/jats:italic>\n = 0.00), unlike B12 (\u03c1 =0.33,\n P<\/jats:italic>\n = 0.11).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Serum homocysteine is a better diagnostic indicator of cognitive impairment than B12. In resource-limited settings, screening with the Mini-Cog test and timely supplementation with B complex vitamins (B6, B12, and folic acid) can slow the progress of dementia in AD patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/aam.aam_592_26","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:05:25Z","timestamp":1786021525000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Association of Serum Homocysteine and Vitamin B12 with Different Grades of Cognitive Impairment in Alzheimer\u2019s Disease Patients"],"prefix":"10.4103","author":[{"given":"Tanima","family":"Mandal","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Bangur Institute of Neurosciences, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Sinharoy","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine, Bangur Institute of Neurosciences, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koushik","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, All India Institute of Medical Sciences, Raebareli, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinaki","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atanu","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine, Bangur Institute of Neurosciences, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,6]]},"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_592_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:05:25Z","timestamp":1786021525000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_592_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/aam.aam_592_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,6]]},"assertion":[{"value":"2026-05-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}