{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:32:05Z","timestamp":1787070725116,"version":"build-2736575974"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Postoperative nausea and vomiting (PONV) are a prevalent complication after laparoscopic surgeries, with an incidence reaching up to 63% without antiemetic prophylaxis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate the efficacy of dexamethasone and ondansetron in preventing PONV in patients undergoing elective laparoscopic cholecystectomy (LC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This prospective, randomized, double-blinded clinical trial. Patients scheduled for elective LC under general anesthesia were randomized to receive either ondansetron (100 \u03bcg\/kg) or dexamethasone (100 \u03bcg\/kg). PONV was assessed at various postoperative intervals. Primary outcomes included the incidence and severity of PONV, while secondary outcomes included the need for rescue antiemetics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 52 patients (Group D: 26 and Group O: 26) were included in the study. The incidence of immediate PONV was 3.8% in Group D and 0% in Group O (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.313). No significant difference was observed between groups at 1\u20132 h and 4 h, and no PONV was reported at 8-, 12-, or 24-h intervals in either group. Vomiting episodes were noted in 15.4% of Group D and 23.1% of Group O patients. Rescue antiemetic use was higher in Group O (34.6%) compared to Group D (19.2%), with no significant difference between the groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.211).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Dexamethasone and ondansetron are both effective for PONV prophylaxis in patients undergoing LC, with comparable efficacy, although ondansetron may require slightly more frequent use of rescue antiemetics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aam.aam_60_26","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:00:29Z","timestamp":1781870429000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Dexamethasone versus Ondansetron for Postoperative Nausea and Vomiting in Laparoscopic Cholecystectomy"],"prefix":"10.4103","author":[{"given":"Pranay","family":"Loomba","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvajit","family":"Podder","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. D. Arun","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,6,19]]},"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_60_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:35:32Z","timestamp":1787067332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_60_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/aam.aam_60_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,19]]},"assertion":[{"value":"2026-01-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}