{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:59:04Z","timestamp":1790272744545,"version":"4.1.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Rheumatoid arthritis (RA) in the elderly is a clinically distinct entity with unique presenting features, serological profiles, and high disease burden. Elderly-onset RA (EORA), defined as RA with onset at or after 65 years, remains understudied in the Indian population despite its growing prevalence.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n To characterize the clinical profile of elderly RA patients and to evaluate the correlation between serological status and disease activity as measured by disease activity score 28-erythrocyte sedimentation rate (DAS28-ESR).<\/jats:p>\n <\/jats:sec>\n \n Methodology:<\/jats:title>\n A cross-sectional observational study was conducted at a tertiary care centre enrolling 120 elderly patients (aged \u226560 years) diagnosed with RA by ACR\/EULAR 2010 criteria. Clinical, laboratory, serological, and disease activity parameters were systematically recorded.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The mean age was 67.53 \u00b1 6.047 years; 66.7% were female. Classical RA was the most common clinical form (70%), followed by polymyalgia rheumatica-like (25%) and remitting seronegative symmetrical synovitis with pitting edema (RS3PE)-like (5%), with a significant association between the RS3PE-like form and advancing age (\n P<\/jats:italic>\n = 0.005). Acute onset was observed in 70%. The shoulder was the most commonly involved joint (43.3%). Proximal interphalangeal joint involvement was significantly higher in YORA (37.9% vs. 14.8%;\n P<\/jats:italic>\n = 0.007), whereas ankle joint involvement was significantly higher in EORA (27.8% vs. 7.6%;\n P<\/jats:italic>\n = 0.006). Asymmetric joint involvement was significantly more common in EORA (66.7% vs. 42.4%;\n P<\/jats:italic>\n = 0.010). RF positivity was 71.7%, anti-cyclic citrullinated peptide (CCP) 69.2%, and overall seropositivity 78.3%. Anti-CCP positivity was significantly associated with high disease activity (\n P<\/jats:italic>\n = 0.020), and overall seropositivity was significantly associated with disease activity category (\n P<\/jats:italic>\n = 0.033). Mean ESR was 56.41 \u00b1 20.369 mm\/h, C-reactive protein was 38.97 \u00b1 19.467 mg\/L, and hemoglobin was 11.86 \u00b1 1.246 g\/dL. The mean DAS28-ESR was 5.28 \u00b1 0.857; 63.3% had high, and 34.2% had moderate disease activity. Hypertension (30%) and diabetes mellitus (18.3%) were the most prevalent comorbidities. Only 34.2% were on disease-modifying antirheumatic drugs (DMARDs) at enrollment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n RA in the Indian elderly population is characterized by acute onset, large joint involvement, high serological positivity, elevated inflammatory markers, and predominantly high disease activity. Anti-CCP positivity is a significant predictor of high disease activity. The high comorbidity burden and suboptimal DMARD utilization underscore the need for early diagnosis and comprehensive multidisciplinary management.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/aam.aam_679_26","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:00:11Z","timestamp":1790269211000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Correlation of Serological Status with Disease Activity Score 28-Erythrocyte Sedimentation Rate Score in Elderly Patients with Rheumatoid Arthritis: A Cross-sectional Study"],"prefix":"10.4103","author":[{"given":"Shubhangi","family":"Kanitkar","sequence":"first","affiliation":[{"name":"Department of General Medicine, Dr. D. Y. Patil Medical College Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, (Deemed to be University), Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Sai Rohith","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Dr. D. Y. Patil Medical College Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, (Deemed to be University), Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimmagadda","family":"Panindra","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Dr. D. Y. Patil Medical College Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, (Deemed to be University), Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanamatareddy Sai Abhinav","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Dr. D. Y. Patil Medical College Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, (Deemed to be University), Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harnoor Kaur","family":"Sekhon","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Dr. D. Y. Patil Medical College Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, (Deemed to be University), Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,9,24]]},"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_679_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:00:11Z","timestamp":1790269211000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_679_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/aam.aam_679_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]},"assertion":[{"value":"2026-05-25","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-31","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}