{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:32:52Z","timestamp":1786649572083,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10]]},"abstract":"\n Context:<\/jats:title>\n Fine-needle aspiration cytology (FNAC) is widely utilized for thyroid lesion diagnosis but faces challenges such as sample inadequacy and overlapping cytological features. This study examines how accurately these patterns correlate with histopathological diagnoses, shedding light on FNAC\u2019s limitations and diagnostic potential.<\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n To study the application of the architectural pattern of follicular cells in the interpretation of thyroid lesions and to demonstrate the diagnostic accuracy (DA) of FNAC.<\/jats:p>\n <\/jats:sec>\n \n Settings and Design:<\/jats:title>\n Cross-sectional study carried over 1 year.<\/jats:p>\n <\/jats:sec>\n \n Subjects and Methods:<\/jats:title>\n A total of 110 cases were reviewed by the cytopathologists. The prominent follicular cell architecture, namely macrofollicular, microfollicular, papillary, trabecular, three-dimensional clusters, and dispersed cells, was described in each case. In addition to these patterns, cellular morphology and background features were also noted, and a final cytological diagnosis was established. The cytology diagnosis was correlated with the histopathological diagnosis.<\/jats:p>\n <\/jats:sec>\n \n Statistical Analysis Used:<\/jats:title>\n Sensitivity, specificity, positive predictive value, negative predictive value, DA of FNAC in diagnosing nonneoplastic and neoplastic lesions.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Macrofollicular pattern was seen in 80.26% of colloid goiter cases. Microfollicular pattern was observed in 72.2% of follicular neoplasm. About 62.5% of papillary thyroid carcinomas showed a papillary pattern. The trabecular pattern was seen in 42.86% of chronic lymphocytic thyroiditis and 16.67% of follicular neoplasms. The sensitivity and specificity of FNAC in diagnosing neoplastic lesions was 92.59% and 97.59%, respectively.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n FNAC is a simple, rapid, definite, and cost-effective primary diagnostic tool for thyroid evaluation. Cell architecture pattern is a simple and appropriate approach that complements cell morphology and background details in arriving at the final cytological diagnosis of thyroid lesions.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/aam.aam_67_24","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T03:00:47Z","timestamp":1723604447000},"page":"623-627","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Follicular Cell Pattern Analysis in Thyroid Fine-needle Aspiration Cytology Evaluation"],"prefix":"10.4103","volume":"23","author":[{"given":"Sasidharannair Chandrakumari","family":"Abilash","sequence":"first","affiliation":[{"name":"Department of Pathology, Windsor University School of Medicine, Cayon, St. Kitts, West Indies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Singaravelu Shree Lakshmi","family":"Devi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Windsor University School of Medicine, Cayon, St. Kitts, West Indies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinha","family":"Pammy","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sri Lakshmi Narayana Institute of Medical Sciences, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"R1-20260427","doi-asserted-by":"crossref","first-page":"13.","DOI":"10.4103\/0970-9371.40652","article-title":"Role of fine needle aspiration cytology in diagnosis and management of thyroid lesions: A study on 434 patients","volume":"25","author":"Handa","year":"2008","journal-title":"J Cytol"},{"key":"R2-20260427","doi-asserted-by":"crossref","first-page":"527","DOI":"10.18231\/j.ijpo.2020.106","article-title":"Thyroid lesions-cytological evaluation by Bethesda system","volume":"7","author":"Tamane","year":"2020","journal-title":"Indian J Pathol Oncol"},{"key":"R3-20260427","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.15537\/smj.2020.10.25417","article-title":"Role of fine-needle aspiration cytology in evaluating thyroid nodules. 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Review of cytomorphologic features in 441 cases","volume":"43","author":"Das","year":"1999","journal-title":"Acta Cytol"},{"key":"R16-20260427","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/cncr.20610","article-title":"Fine-needle aspiration cytology of solitary thyroid nodules: How far can we go in rendering differential cytologic diagnoses?","volume":"102","author":"Ers\u00f6z","year":"2004","journal-title":"Cancer"},{"key":"R17-20260427","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/1097-0142(20001225)90:6<335::AID-CNCR3>3.0.CO;2-L","article-title":"Follicular lesions of thyroid: A 5-year fine-needle aspiration experience","volume":"90","author":"Greaves","year":"2000","journal-title":"Cancer"}],"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_67_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:55:32Z","timestamp":1786647332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_67_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,13]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/aam.aam_67_24","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,13]]},"assertion":[{"value":"2024-04-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}