{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:59:25Z","timestamp":1790067565967,"version":"4.0.1"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,11]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Bicytopenia is defined as a reduction in any two of the three major blood cell lineages and may result from a wide spectrum of infectious, nutritional, hematological, and systemic disorders. Early identification of the underlying etiology is essential for appropriate management.<\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n To study the etiological spectrum, hematological profile, clinical presentation, and patterns of bicytopenia among patients attending a tertiary care Center.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n The study analyzed the clinical and hematological profile of 110 patients with bicytopenia. Patients were categorized based on age, gender, hematological parameters, etiologies, symptoms, and type of bicytopenia. Statistical analysis was performed using the Chi-square test.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Patients in the study had a mean age of 41.5 \u00b1 15.42 years with female predominance (54.5%). Viral fever, including dengue, was the leading cause (23.6%), subsequently nutritional deficiency (13.6%) and sepsis (11.8%). Leukopenia with thrombocytopenia was the most common type of bicytopenia (37.3%). Fever was the predominant presenting symptom (48.2%). The type of bicytopenia showed a significant association with of underlying etiology (\n P<\/jats:italic>\n < 0.0001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Bicytopenia is associated with diverse etiologies ranging from transient infections to serious hematological disorders. Infectious diseases and nutritional deficiencies constituted the major causes in the present study. Recognition of hematological patterns along with systematic clinical evaluation can aid in early diagnosis and timely management.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/aam.aam_680_26","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:01:12Z","timestamp":1788354072000},"page":"1484-1490","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Clinico-Hematological Evaluation of Bicytopenia in Adults: A Hospital-based Observational Study"],"prefix":"10.4103","volume":"25","author":[{"given":"Vidya","family":"Kuchanur","sequence":"first","affiliation":[{"name":"Department of Pathology, KLE Jagadguru Gangadhar Mahaswamigalu Moorusavirmath Medical College and Hospital, KLE Academy of Higher Education and Research, Deemed to be University, Hubli, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Appu","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Medicine, KLE Jagadguru Gangadhar Mahaswamigalu Moorusavirmath Medical College and Hospital, KLE Academy of Higher Education and Research, Deemed to be University, Hubli, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani S.","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology, KLE Jagadguru Gangadhar Mahaswamigalu Moorusavirmath Medical College and Hospital, KLE Academy of Higher Education and Research, Deemed to be University, Hubli, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"R1-20260922","first-page":"62","article-title":"Approach to diagnosis and classification of blood diseases. In: Lewis S, Bain B, Bates I editors. Dacie and Lewis Practical Haematology. 11th ed","volume":"549","author":"Bates","year":"2012","journal-title":"Philadelphia: Churchill Livingstone"},{"key":"R2-20260922","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4103\/0377-4929.77329","article-title":"Pediatric patients with bicytopenia\/pancytopenia: Review of etiologies and clinico-hematological profile at a tertiary center","volume":"54","author":"Naseem","year":"2011","journal-title":"Indian J Pathol Microbiol"},{"key":"R3-20260922","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.pathol.2018.03.008","article-title":"Clinico-hematological profile of patients with bicytopenia","volume":"50","author":"Singh","year":"2018","journal-title":"Pathology"},{"key":"R4-20260922","first-page":"55","article-title":"Bone marrow examination in cases of Pancytopenia","volume":"2","author":"Khodke","year":"2001","journal-title":"JIACM"},{"key":"R5-20260922","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4103\/0974-2727.78555","article-title":"Pancytopenia: A clinico-hematological study","volume":"3","author":"Gayathri","year":"2011","journal-title":"J Lab Physicians"},{"key":"R6-20260922","first-page":"163","article-title":"Etiological spectrum of pancytopenia based on bone marrow examination in children","volume":"18","author":"Memon","year":"2008","journal-title":"J Coll Physicians Surg Pak"},{"key":"R7-20260922","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1258\/td.2008.070422","article-title":"A study of clinico-haematological profiles of pancytopenia in children","volume":"38","author":"Gupta","year":"2008","journal-title":"Trop Doct"},{"key":"R8-20260922","doi-asserted-by":"crossref","first-page":"12","DOI":"10.31729\/jnma.209","article-title":"Bone marrow examination in cases of pancytopenia","volume":"47","author":"Jha","year":"2008","journal-title":"J Nepal Med Assoc"},{"key":"R9-20260922","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/tropej\/fmi010","article-title":"Pancytopenia in children: Etiological profile","volume":"51","author":"Bhatnagar","year":"2005","journal-title":"J Trop Pediatr"},{"key":"R10-20260922","first-page":"12","article-title":"Clinico-hematological analysis of pancytopenia: A bone marrow study","volume":"2","author":"Javalgi","year":"2013","journal-title":"Natl J Lab Med"}],"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_680_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:00:50Z","timestamp":1790064050000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_680_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,2]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/aam.aam_680_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,2]]},"assertion":[{"value":"2026-05-25","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}