{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:41:25Z","timestamp":1787071285981,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fibromyalgia is a chronic disorder, characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and psychological distress, with limited efficacy from conventional treatments. Ozone therapy, a medical approach that induces controlled oxidative stress to enhance antioxidant defences and modulate immune responses, has emerged as a potential complementary intervention. Evidence suggests that ozone therapy improves pain, fatigue, and sleep quality by correcting oxidative imbalances, enhancing oxygen utilization, and regulating inflammatory pathways. Clinical studies, report significant symptom relief in up to 70% of patients, with minimal adverse effects when administered according to standardized protocols. Despite promising outcomes, the current literature is constrained by small sample sizes, heterogeneity in study designs, and limited long-term follow-up data. Future research should focus on large-scale, well-designed trials, standardized treatment protocols, and mechanistic studies to establish ozone therapy\u2019s role in fibromyalgia management.<\/jats:p>","DOI":"10.4103\/aam.aam_682_25","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T07:00:20Z","timestamp":1775545220000},"page":"760-763","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the Efficacy of Ozone Therapy in Fibromyalgia"],"prefix":"10.4103","volume":"25","author":[{"given":"Prakhar","family":"Saxena","sequence":"first","affiliation":[{"name":"Department of Ozone, National Institute of Naturopathy, Ministry of Ayush, Government of India, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyalakshmi","family":"Komarraju","sequence":"additional","affiliation":[{"name":"Department of Naturopathy and Yoga, National Institute of Naturopathy, Ministry of Ayush, Government of India, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Sathyanath","sequence":"additional","affiliation":[{"name":"Department of Natural Therapeutics, National Institute of Naturopathy, Ministry of Ayush, Government of India, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrikanth","family":"Muralidharan","sequence":"additional","affiliation":[{"name":"Department of Research, National Institute of Naturopathy, Ministry of Ayush, Government of India, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"R1-20260803","first-page":"1786","article-title":"Ozone therapy in 65 patients with fibromyalgia: An effective therapy","volume":"23","author":"Tirelli","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"R2-20260803","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3233\/BMR-210368","article-title":"Efficacy of ozone therapy as an add-on treatment in fibromyalgia: A randomized double-blind placebo-controlled study","volume":"36","author":"Sucuo\u011flu","year":"2023","journal-title":"J Back Musculoskelet Rehabil"},{"key":"R3-20260803","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1089\/acm.2011.0739","article-title":"Ozone therapy as add-on treatment in fibromyalgia management by rectal insufflation: An open-label pilot study","volume":"19","author":"Hidalgo-Tall\u00f3n","year":"2013","journal-title":"J Altern Complement Med"},{"key":"R4-20260803","doi-asserted-by":"crossref","first-page":"287","DOI":"10.67442\/tmy59j77","article-title":"Ozone therapy as a complementary treatment in fibromyalgia","volume":"11","author":"da Costa","year":"2021","journal-title":"A systematic review. Ozone Ther Glob J"},{"key":"R5-20260803","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4103\/0976-9668.82319","article-title":"Ozone therapy: A clinical review","volume":"2","author":"Elvis","year":"2011","journal-title":"J Nat Sci Biol Med"},{"key":"R6-20260803","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4103\/2045-9912.215752","article-title":"Ozone therapy: An overview of pharmacodynamics, current research, and clinical utility","volume":"7","author":"Smith","year":"2017","journal-title":"Med Gas Res"},{"key":"R8-20260803","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1186\/s40001-024-01976-4","article-title":"Ozone therapy in musculoskeletal medicine: A comprehensive review","volume":"29","author":"Jeyaraman","year":"2024","journal-title":"Eur J Med Res"},{"key":"R9-20260803","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1479-5876-9-66","article-title":"Ozone acting on human blood yields a hormetic dose-response relationship","volume":"9","author":"Bocci","year":"2011","journal-title":"J Transl Med"},{"key":"R10-20260803","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.arcmed.2007.07.005","article-title":"Ozone therapy: Clinical and basic evidence of its therapeutic potential","volume":"39","author":"Re","year":"2008","journal-title":"Arch Med Res"},{"key":"R11-20260803","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejphar.2005.08.020","article-title":"Therapeutic efficacy of ozone in patients with diabetic foot","volume":"523","author":"Mart\u00ednez-S\u00e1nchez","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"R12-20260803","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0891-5849(94)90172-4","article-title":"Mechanisms of radical formation from reactions of ozone with target molecules in the lung","volume":"17","author":"Pryor","year":"1994","journal-title":"Free Radic Biol Med"}],"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_682_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:44:08Z","timestamp":1787067848000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_682_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,7]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/aam.aam_682_25","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,7]]},"assertion":[{"value":"2025-10-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}