{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T08:45:26Z","timestamp":1791794726791,"version":"4.3.4"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>Baveno VII criteria prioritize Liver Stiffness Measurement (LSM) for portal hypertension risk stratification, primarily using transient elastography. We aimed to evaluate two-dimensional-shear wave elastography (2D-SWE) cutoffs, assess the etiology-dependent utility of spleen stiffness (SSM), and introduce a novel Combined Hepato-splenic Stiffness Index (CHSSI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This ambispective, observational study enrolled 100 chronic liver disease patients. Participants underwent 2D-SWE for LSM and SSM, alongside endoscopy as the reference standard. A novel multiparametric index, CHSSI, was formulated. Diagnostic accuracy for Varices Needing Treatment (VNT; Grade &gt;= II) was assessed using area under the receiver operating characteristic (AUROC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The cohort was predominantly Alcohol-related Liver Disease (ALD, 49%) and Viral Hepatitis (30%). LSM independently predicted VNT (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), with an optimal 2D-SWE cutoff of 19.2 kPa (sensitivity 90% and specificity 82%). SSM utility diverged by etiology: it correlated significantly with variceal grade in ALD (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.549,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) but poorly in viral cirrhosis (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.174,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.358). The novel CHSSI demonstrated excellent diagnostic performance (AUROC 0.892) for predicting VNT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Liver stiffness remains the most robust single-parameter surrogate for esophageal varices. However, in heterogeneous cohorts where splenic stiffness alone yields inconsistent results, novel composite indices such as CHSSI and Liver Size-stiffness Index offer superior discriminative ability. These findings support a refined noninvasive risk stratification strategy, potentially reducing unnecessary screening endoscopies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aam.aam_695_26","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T08:00:11Z","timestamp":1791792011000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Validation of Baveno VII Criteria using Liver and Splenic Elastography for Predicting Esophageal Varices Severity in Chronic Liver Disease: A Multiparametric, Observational Study"],"prefix":"10.4103","author":[{"given":"Manish","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Radiodiagnosis, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virendra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priti","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Ramkrishna Care Hospital, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanmay","family":"Vajpai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,10,13]]},"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_695_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T08:00:12Z","timestamp":1791792012000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_695_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,13]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/aam.aam_695_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,13]]},"assertion":[{"value":"2026-05-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}