{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:37:03Z","timestamp":1786649823219,"version":"build-2736575974"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Therapeutic plasma exchange (TPE) is an established immunomodulatory therapy with proven efficacy in a wide range of neurological disorders. In recent years, expanding indications, combined with cost-effectiveness and a favorable safety profile, have increased their relevance, particularly in low-resource settings where access to intravenous immunoglobulin may be limited. This study analyzes our institutional experience with TPE in the management of diverse neurological conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective observational study over a 5-year period (January 2015\u2013December 2019) at the transfusion medicine department of a tertiary care neurological center. TPE was performed with a target plasma removal of 150\u2013200 mL\/kg body weight per session, using appropriate replacement fluids. Data regarding patient demographics, neurological indications, American Society for Apheresis indication categories, number of procedures, and procedure-related complications were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 13,387 TPE procedures were performed in 2507 patients, with ages ranging from 9 to 86 years (mean age: 38.18 years). Guillain\u2013Barr\u00e9 syndrome was the most common indication, accounting for 56.20% of cases, followed by other immune-mediated neurological disorders. Hypotension was the most frequently observed adverse event. Importantly, no procedure-related mortality was recorded during the study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Therapeutic plasmapheresis is a safe, effective, and adaptable treatment modality for a broad spectrum of neurological disorders. Its favorable safety profile and clinical utility support its role as a valuable and sustainable therapeutic option, particularly in low-resource healthcare settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aam.aam_6_26","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:00:09Z","timestamp":1776405609000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Adaptive Therapeutic Plasma Exchange Technologies in Low-resource Settings: Utilization, Safety, and Clinical Insights from 2507 Neurological Cases"],"prefix":"10.4103","author":[{"given":"Vijay","family":"Kumawat","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine and Haematology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parmatma Prasad","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Haematology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidyashree Anchan","family":"Vittal","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Haematology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4,16]]},"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_6_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:58:48Z","timestamp":1786647528000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_6_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,16]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/aam.aam_6_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,16]]},"assertion":[{"value":"2026-01-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-11","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}