{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:50:02Z","timestamp":1791442202802,"version":"4.3.3"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Chronic obstructive pulmonary disease (COPD) is a major global health issue, with pulmonary hypertension (PH) as a severe complication linked to increased morbidity and mortality. Endothelin-1 (ET-1) is a vasoconstrictor peptide and a potential biomarker for PH in COPD due to its role in vascular remodeling and hemodynamic stress.<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n This study aimed to assess serum ET-1 levels in COPD patients with and without PH to evaluate its correlation with hemodynamic and metabolic parameters and evaluate its diagnostic potential.<\/jats:p>\n <\/jats:sec>\n \n Methodology:<\/jats:title>\n \n A cross-sectional study enrolled 90 subjects (46 COPD with PH, 24 COPD without PH, 20 controls) from January 2023 to December 2024. COPD was confirmed via spirometry (forced expiratory volume in 1 s\/forced vital capacity <0.70) and PH defined as mean pulmonary artery pressure (MPAP) >20 mmHg by right heart catheterization or echocardiography. Serum ET-1 was measured using enzyme-linked immunosorbent assay. Data included clinical history, spirometry, hemodynamics, and hemoglobin A1c (HbA1c). Statistical analysis involved analysis of variance,\n post-hoc<\/jats:italic>\n tests, bivariate correlations and multivariate regression (\n P<\/jats:italic>\n < 0.05 significant).\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n ET-1 levels were significantly elevated in COPD with PH (26.6 \u00b1 16.87 pg\/mL) versus COPD without PH (17.96 \u00b1 18.43 pg\/mL) and controls (3.3 \u00b1 1.48 pg\/mL,\n P<\/jats:italic>\n < 0.001). MPAP (27.46 \u00b1 5.62 mmHg vs. 15.02 \u00b1 1.28 and 15.23 \u00b1 1.17 mmHg,\n P<\/jats:italic>\n < 0.001) and right atrial (RA) pressure (12.17 \u00b1 2.76 vs. 5.75 \u00b1 0.87 and 5.7 \u00b1 0.82 mmHg,\n P<\/jats:italic>\n < 0.001) distinguished the PH group. ET-1 correlated with MPAP (\n P<\/jats:italic>\n = 0.001), RA pressure (\n P<\/jats:italic>\n = 0.002), and HbA1c (\n P<\/jats:italic>\n = 0.003), with HbA1c as an independent predictor (odds ratio: 4.66, 95% confidence interval 0.748\u20138.58,\n P<\/jats:italic>\n = 0.0203). No correlations were observed with smoking (\n P<\/jats:italic>\n = 0.83) or lung function (\n P<\/jats:italic>\n = 0.295). Echocardiographic markers (\n P<\/jats:italic>\n < 0.014) supported PH diagnosis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Elevated ET-1 marked PH severity in COPD, with a novel metabolic link to HbA1c, which suggested its utility as a non-invasive diagnostic tool.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/aam.aam_712_26","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:00:54Z","timestamp":1791439254000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Estimation of Endothelin Levels in Chronic Obstructive Pulmonary Disease Patients with Pulmonary Hypertension: A Clinical Insight"],"prefix":"10.4103","author":[{"given":"Jyoti","family":"Bajpai","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshyaya","family":"Pradhan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Kaleem","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surya","family":"Kant","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,10,7]]},"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_712_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:00:54Z","timestamp":1791439254000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_712_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/aam.aam_712_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"assertion":[{"value":"2026-06-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-31","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}