{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:41:15Z","timestamp":1787071275054,"version":"build-2736575974"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Propofol is widely used for the induction of general anesthesia but is associated with dose-dependent hypotension. Fentanyl, when administered before propofol, may reduce the propofol dose requirement and mitigate hemodynamic instability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the effect of varying time intervals between fentanyl and propofol administration on propofol dose requirement for induction and to assess associated hemodynamic responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      This randomized controlled study enrolled 150 American Society of Anesthesiologists I\u2013II patients aged 18\u201360 years scheduled for elective surgery under general anesthesia. Patients were allocated into three groups (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 50 each): Group 1 received propofol immediately after fentanyl (2 \u03bcg\/kg intravenous), Group 2 after 3 min, and Group 3 after 5 min. Propofol was titrated until loss of verbal response. Hemodynamic parameters were recorded at baseline, postfentanyl, during induction, and postintubation. Incidence of hypotension, movements, bucking, and vocalization were noted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Group 3 required significantly less propofol (67.6 \u00b1 16.36 mg) than Group 2 (104.6 \u00b1 21.2 mg) and Group 1 (137.8 \u00b1 12.41 mg) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The incidence of hypotension was lowest in Group 3 (3%) compared with Group 2 (21%) and Group 1 (45%) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Group 3 also showed better attenuation of the intubation response and fewer adverse movements.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Administering propofol 5 min after fentanyl significantly reduces induction dose requirements and improves haemodynamic stability during induction and intubation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aam.aam_715_25","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T06:00:13Z","timestamp":1775541613000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A Study of the Effect of Varying Time Intervals between Fentanyl and Propofol on Propofol Requirement for Induction of General Anesthesia: A Randomized Prospective Controlled Study"],"prefix":"10.4103","author":[{"given":"B.","family":"Prathvi","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Asif","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, KLE JGMMMC, Hubli KLE Academy of Higher Education and Research, Hubballi, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Akshatha","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Vydehi Medical College, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4,6]]},"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_715_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:44:00Z","timestamp":1787067840000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_715_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,6]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/aam.aam_715_25","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,6]]},"assertion":[{"value":"2025-11-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}