{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:24:56Z","timestamp":1787837096980,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Endometrial polyps are common benign growths; however, exceptionally large polyps are rare and may present with severe clinical symptoms. Surgical intervention is often necessary to manage complications, and histopathological evaluation is crucial to assess their oncogenic potential. Accordingly, the aim of this study is to evaluate the clinical presentation, surgical management, and oncogenic potential of unusually large uterine polyps to emphasize the importance of early diagnosis and timely intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This retrospective study analyzed data from 200 patients undergoing hysteroscopic polypectomy for uterine polyps exceeding 3 cm in size. Preoperative assessments included ultrasonography, hysteroscopy, and histopathological evaluation. Surgical outcomes, histopathological findings, and postsurgical follow-up data over 2 years were documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among the 200 patients examined, three cases were identified with unusually large endometrial polyps, each presenting with severe clinical symptoms. Case 1 involved a 35-year-old woman with severe suprapubic pain, anemia, and a protruding vaginal mass. Magnetic resonance imaging (MRI) revealed an 8.49 cm posterior endometrial polyp extending to the posterior cervical wall. Case 2 was a 32-year-old woman with urinary difficulty, menorrhagia, and anemia. MRI identified two uterine polyps, the largest measuring 11.45 cm \u00d7 6.1 cm, extending up to the cervix. Case 3 was a 43-year-old woman with urinary retention, continuous vaginal bleeding, and a massive 21.4 cm \u00d7 8.65 cm \u00d7 8.0 cm polyp originating from the fundal region. Hysterectomy was performed in all cases, and histopathological evaluation confirmed benign polyps without malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The occurrence of massive uterine polyps is rare but can lead to severe symptoms and significant morbidity. While histopathology confirmed benign pathology in these cases, the potential for malignant transformation underscores the need for early diagnosis and timely surgical intervention. MRI plays a crucial role in preoperative assessment, and hysterectomy remains the definitive treatment for large polyps causing severe clinical symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aam.aam_73_25","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T03:01:09Z","timestamp":1748833269000},"page":"252-256","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Surgical Intervention of Huge Uterine Polyp and its Oncogenic Potential and Clinical Implications"],"prefix":"10.4103","volume":"25","author":[{"given":"Thapasya Reddy","family":"Gaddam","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Varun Arjun University, Banthra-Shahjahanpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuri Kalyan","family":"Chakravarthi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Manipal University College Malaysia, Malacca City, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"R1-20260311","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1097\/AOG.0b013e3181f74864","article-title":"The oncogenic potential of endometrial polyps:A systematic review and meta-analysis","volume":"116","author":"Lee","year":"2010","journal-title":"Obstet Gynecol"},{"key":"R2-20260311","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.3390\/biomedicines11102609","article-title":"Transvaginal ultrasound versus magnetic resonance imaging:What is the optimal imaging modality for the diagnosis of endometriosis?","volume":"11","author":"Bau\u015fic","year":"2023","journal-title":"Biomedicines"},{"key":"R3-20260311","doi-asserted-by":"crossref","first-page":"1","DOI":"10.17077\/2154-4751.1230","article-title":"Giant endometrial polyp protruding from the external cervical os in a postmenopausal woman:Magnetic resonance imaging and hysteroscopic findings","volume":"3","author":"Cil","year":"2013","journal-title":"Proc Obstet Gynecol"},{"key":"R4-20260311","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1055\/s-2007-1023693","article-title":"Giant polyp of the cervix","volume":"51","author":"Branger","year":"1991","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"R5-20260311","doi-asserted-by":"crossref","first-page":"836","DOI":"10.5468\/KJOG.2011.54.12.836","article-title":"A giant endometr\u0131al polyp w\u0131th tamox\u0131fen therapy \u0131n postmenopausal woman","volume":"54","author":"Moon","year":"2011","journal-title":"Korean J Obstet Gynecol"},{"key":"R6-20260311","first-page":"D06","article-title":"Story of a giant endometrial polyp in asymptomatic postmenopausal female","volume":"11","author":"Meena","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"R7-20260311","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1097\/MS9.0000000000001667","article-title":"Giant endometrial polyp in a post-menopausal woman:A rare case report from Nepal","volume":"86","author":"Pokhrel","year":"2024","journal-title":"Ann Med Surg (Lond)"},{"key":"R8-20260311","first-page":"8753463","article-title":"Oncogenic potential and clinical implications of giant endometrial polyps:A case report and literature review","author":"van Staalduinen","year":"2018","journal-title":"Case Rep Obstet Gynecol, 2018"},{"key":"R9-20260311","first-page":"1170","article-title":"Case series for giant endometrial polyp:A clinicopathological evaluation, management and review literature","volume":"14","author":"Tyagi","year":"2023","journal-title":"J Cardiovasc Dis Res"},{"key":"R10-20260311","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/00004347-199610000-00007","article-title":"Estrogen and progesterone receptor expression in endometrial polyps","volume":"15","author":"Mittal","year":"1996","journal-title":"Int J Gynecol Pathol"},{"key":"R11-20260311","first-page":"e12789","article-title":"Giant endometrial polyp in a postmenopausal woman","volume":"13","author":"Nair","year":"2021","journal-title":"Cureus"}],"container-title":["Annals of African 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