{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:46:09Z","timestamp":1791812769792,"version":"4.3.4"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pilomyxoid astrocytoma (PMA) is an uncommon variant of pilocytic astrocytoma, distinguished by unique histological features and a relatively aggressive clinical course. While classically seen in infants and young children, PMA in adults, especially in the suprasellar region, is exceedingly rare. We report a 42-year-old woman presenting with progressive visual decline and headaches. Imaging suggested a craniopharyngioma. Endoscopic endonasal transsphenoidal resection achieved gross total excision. Histopathology confirmed PMA, central nervous system World Health Organization Grade 1. Postoperatively, the patient experienced significant visual improvement with no new deficits. Follow-up magnetic resonance imaging demonstrated complete tumor removal and no evidence of recurrence at early surveillance. This case highlights the diagnostic challenge of adult suprasellar PMA, which may mimic craniopharyngioma radiologically. Recognition of PMA in adults is crucial, as advances in molecular diagnostics and minimally invasive surgery support tailored management and favorable outcomes.<\/jats:p>","DOI":"10.4103\/aam.aam_75_26","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:00:26Z","timestamp":1789639226000},"page":"S490-S493","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Adult Pilomyxoid Astrocytoma Mimicking a Craniopharyngioma: An Unusual Suprasellar Presentation"],"prefix":"10.4103","volume":"25","author":[{"given":"Sarang","family":"Gotecha","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Addagada","family":"Avinash","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Chugh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Punia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"R1-20261012","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1097\/00005072-199910000-00004","article-title":"Pediatric astrocytomas with monomorphous pilomyxoid features and a less favorable outcome","volume":"58","author":"Tihan","year":"1999","journal-title":"J Neuropathol Exp Neurol"},{"issue":"(6)","key":"R2-20261012","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.1227\/01.neu.0000309458.92298.bb","article-title":"Pilomyxoid astrocytoma: Diagnosis, prognosis, and management","volume":"18","author":"Komotar","year":"2005","journal-title":"Neurosurg Focus"},{"key":"R3-20261012","first-page":"259","article-title":"Pilomyxoid astrocytoma: A distinctive low-grade astrocytoma","volume":"10","author":"Choudhury","year":"2000","journal-title":"Brain Pathol"},{"key":"R4-20261012","first-page":"522","article-title":"Molecular characterization of pilomyxoid astrocytoma: MAPK pathway alterations and developmental gene expression","volume":"24","author":"Rodriguez","year":"2014","journal-title":"Brain Pathol"},{"key":"R5-20261012","first-page":"1238","article-title":"Perfusion and advanced imaging of pilomyxoid astrocytomas: Diagnostic insights","volume":"41","author":"Menda","year":"2020","journal-title":"AJNR Am J Neuroradiol"},{"key":"R6-20261012","doi-asserted-by":"crossref","first-page":"667","DOI":"10.4103\/0973-1482.138102","article-title":"Pilomyxoid astrocytoma in an adult woman: Case report","volume":"11","author":"Kibola","year":"2015","journal-title":"J Cancer Res Ther"},{"key":"R7-20261012","first-page":"456","article-title":"Pilomyxoid astrocytoma in adults: Case series and literature review","volume":"13","author":"Alnajjar","year":"2022","journal-title":"Surg Neurol Int"},{"key":"R8-20261012","first-page":"240","article-title":"Pilomyxoid astrocytoma of the temporal lobe in an adult: Case report and review of the literature","volume":"71","author":"Dong","year":"2023","journal-title":"Neurol India"},{"key":"R9-20261012","first-page":"551","article-title":"Differentiation of pilocytic and pilomyxoid astrocytomas using dynamic susceptibility contrast perfusion and diffusion weighted imaging","volume":"61","author":"Das","year":"2019","journal-title":"Neuroradiology"},{"key":"R10-20261012","first-page":"E1","article-title":"Endoscopic endonasal transsphenoidal surgery: History and evolution","volume":"19","author":"Cavallo","year":"2005","journal-title":"Neurosurg Focus"},{"key":"R11-20261012","first-page":"755","article-title":"Pilomyxoid astrocytoma: Pathology, molecular insights, and clinical management","volume":"137","author":"Gessi","year":"2019","journal-title":"Acta Neuropathol"}],"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_75_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:01:46Z","timestamp":1791810106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_75_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,17]]},"references-count":11,"journal-issue":{"issue":"Suppl 3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/aam.aam_75_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,17]]},"assertion":[{"value":"2026-01-24","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}