{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T15:29:48Z","timestamp":1786375788276,"version":"build-2736575974"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"Abstract<\/jats:title>\n \n Introduction:<\/jats:title>\n \n Toxoplasma gondii<\/jats:italic>\n infects one-third of the global human population and invades and chronically persists in the central nervous system of the infected host. Chronic infection in the brain correlates with changes in the neuronal architecture and behavior. To the best of our knowledge, the association between\n T. gondii<\/jats:italic>\n and neurological and psychiatric disorders has not been studied in the Indian population. Therefore, this study was conducted to determine the association between\n T. gondii<\/jats:italic>\n in these patients.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n This cross-sectional study was conducted in a large Neuroscience Center by the Department of Microbiology in collaboration with the Psychiatry and Neurology Departments for 7 months from March to September 2025. A total of 281 neuropsychiatric patients and an equal number of controls were taken. They were further classified using the International Classification of Diseases, ICD-10 codes. After carefully explaining the procedure and goal of the study, informed written consent was taken. 3 mL of blood specimens was drawn under aseptic conditions by venipuncture, which was collected in sterile plain vials. Serum samples were tested for the presence of specific anti-\n T. gondii<\/jats:italic>\n immunoglobulin G antibodies using a commercial qualitative enzyme-linked immunosorbent assay.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Our results reveal a higher prevalence of\n T. gondii<\/jats:italic>\n antibodies among schizophrenia (33.34%), mental and behavioral disorder due to substance abuse (30%), bipolar affective disorder (32%), Parkinson\u2019s disease (31.03%), and dementia (35%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Our results suggest that\n T. gondii<\/jats:italic>\n seropositivity is higher among the psychiatric and neurological patients, but it is not significantly associated as compared to controls.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/aam.aam_76_26","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T15:00:15Z","timestamp":1786374015000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Seroprevalence Study of Toxoplasma gondii Infection in Psychiatric and Neurological Disorders"],"prefix":"10.4103","author":[{"given":"Sonali","family":"Maheshwari","sequence":"first","affiliation":[{"name":"Department of Microbiology, Institute of Human Behaviour and Allied Sciences, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Maheshwari","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Human Behaviour and Allied Sciences, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajinder K.","family":"Dhamija","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Human Behaviour and Allied Sciences, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Institute of Human Behaviour and Allied Sciences, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Kushwaha","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Human Behaviour and Allied Sciences, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mridula","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Human Behaviour and Allied Sciences, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Institute of Human Behaviour and Allied Sciences, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahadev Singh","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Institute of Human Behaviour and Allied Sciences, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,10]]},"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_76_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T15:00:15Z","timestamp":1786374015000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_76_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/aam.aam_76_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,10]]},"assertion":[{"value":"2026-01-25","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}