{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:13:02Z","timestamp":1789560782282,"version":"build-2803163510"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fissured tongue is a benign oral condition characterized by grooves or fissures on the dorsal surface of the tongue and is often considered idiopathic. However, it has occasionally been reported in association with systemic disorders, including endocrine abnormalities. We report the case of an 18-year-old male who presented with fatigue, cold intolerance, weight gain, and progressive fissuring of the tongue over several years. Intraoral examination revealed multiple prominent fissures on the dorsal surface of the tongue with mild macroglossia. Laboratory investigations demonstrated elevated thyroid-stimulating hormone levels with borderline low free thyroxine and mildly raised antithyroid peroxidase antibodies, findings suggestive of hypothyroidism possibly related to autoimmune thyroid disease. The patient was started on levothyroxine therapy, resulting in improvement of systemic symptoms and normalization of thyroid function tests within 6 months. However, the fissured appearance of the tongue persisted despite biochemical euthyroidism. This case is noteworthy because the patient was a young adult with progressive tongue fissuring preceding diagnosis, a positive family history of thyroid disease, and persistence of fissures despite appropriate thyroid hormone replacement therapy. The report highlights the potential association between oral findings and systemic endocrine disorders and emphasizes the importance of careful oral examination in patients presenting with suggestive systemic symptoms.<\/jats:p>","DOI":"10.4103\/aam.aam_814_25","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T06:00:13Z","timestamp":1775628013000},"page":"S418-S421","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Fissured Tongue associated with Hypothyroidism in a Young Patient"],"prefix":"10.4103","volume":"25","author":[{"given":"Pankaj","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufia","family":"Parveen","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Jawed","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"R1-20260916","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0377-1237(17)30112-0","article-title":"Fissured and burning tongue","volume":"56","author":"Chakraborty","year":"2000","journal-title":"Med J Armed Forces India"},{"key":"R2-20260916","doi-asserted-by":"crossref","first-page":"361","DOI":"10.4103\/2229-5178.137813","article-title":"Lingua plicata","volume":"5","author":"Avhad","year":"2014","journal-title":"Indian Dermatol Online J"},{"key":"R3-20260916","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4103\/0970-4388.100008","article-title":"Benign migratory glossitis with fissured tongue","volume":"30","author":"Goswami","year":"2012","journal-title":"J Indian Soc Pedod Prev Dent"},{"key":"R4-20260916","first-page":"e9480","article-title":"Think Melkersson-Rosenthal syndrome: A fissured tongue with facial paralysis","volume":"12","author":"Ibrahim","year":"2020","journal-title":"Cureus"},{"key":"R5-20260916","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1468-3083.2004.00769.x","article-title":"The tongue in clinical diagnosis","volume":"18","author":"Rogers","year":"2004","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R6-20260916","first-page":"e6318","article-title":"Oral psoriasis of the tongue: A case report","volume":"11","author":"Ferris","year":"2019","journal-title":"Cureus"},{"key":"R7-20260916","first-page":"9","article-title":"Prevalence of fissured tongue in a South Indian population: A cross-sectional study","volume":"1","author":"Mathew","year":"2017","journal-title":"J Oral Med"},{"key":"R9-20260916","doi-asserted-by":"crossref","first-page":"S113","DOI":"10.4103\/2230-8210.83343","article-title":"Oral manifestations of thyroid disorders and its management","volume":"15","author":"Chandna","year":"2011","journal-title":"Indian J Endocrinol Metab"},{"key":"R10-20260916","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1159\/000079590","article-title":"Prevalence of fissured tongue, geographic tongue and median rhomboid glossitis among Israeli adults of different ethnic origins","volume":"209","author":"Yarom","year":"2004","journal-title":"Dermatology"},{"key":"R11-20260916","doi-asserted-by":"crossref","first-page":"e8640","DOI":"10.1002\/ccr3.8640","article-title":"Hypothyroidism presenting as a fissure tongue","volume":"12","author":"Mylaraiah","year":"2024","journal-title":"Clin Case Rep"}],"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_814_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:00:53Z","timestamp":1789560053000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_814_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,8]]},"references-count":10,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/aam.aam_814_25","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,8]]},"assertion":[{"value":"2025-12-10","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}