{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:43:32Z","timestamp":1786653812556,"version":"build-2736575974"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Preeclampsia is a life-threatening complication of pregnancy that occurs in approximately 7% of all pregnancies. In India, the incidence of preeclampsia is 8%\u201310% and the prevalence is 5.4%, whereas the prevalence of hypertensive disorders of pregnancy is 7.8%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim and Objectives:<\/jats:title>\n                    <jats:p>This study was aimed at evaluating the diagnostic accuracy of serum glycosylated fibronectin (S. GlyFn) in the prediction of preeclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A nested case\u2013control study was carried out for 16 months in the department of obstetrics and gynecology. A total of 240 women were recruited and followed after written consent and ethical clearance. Six were lost to follow-up, 15 had second-trimester abortions (excluded from the study), and 32 women developed hypertensive disorders of pregnancy (cases), out of which 1 woman developed antepartum eclampsia, 10 women developed preeclampsia with severe features, and 21 women developed preeclampsia without severe features. One hundred and eighty-seven women remained normotensive throughout the pregnancy until 6 weeks postpartum. After randomization, out of these samples, 54 were analyzed and considered controls. Levels of S. GlyFn were estimated using an ELISA kit using the ELISA technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean S. GlyFn level was significantly higher at the time of enrollment among those women who later developed preeclampsia (127.59 \u00b1 27.68 ng\/m) as compared to controls (107.79\u201353.51 ng\/mL). GlyFn at a cutoff value of 126.70 ng\/mL significantly (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.034) discriminates cases of preeclampsia with severe features from healthy controls with a sensitivity of 90.00%, a specificity of 63.00%, a 31.03% positive predictive value, and 97.14% negative predictive value.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>S. GlyFn, at a cutoff value of 126.70 ng\/mL, had good sensitivity to discriminate PE from normotensive and was also a good prognostic marker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aam.aam_81_23","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:01:07Z","timestamp":1714608067000},"page":"169-175","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic Accuracy of Serum Glycosylated Fibronectin in Prediction of Preeclampsia: A Nested Case\u2013Control Study"],"prefix":"10.4103","volume":"23","author":[{"given":"Rekha","family":"Sachan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pushpa Lata","family":"Sachan","sequence":"additional","affiliation":[{"name":"Department of Physiology, Uttar Pradesh Autonomous State Medical College, Hardoi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazrana","family":"Ghayyur","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munna Lal","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Medicine, King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wahid","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pathology, King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,5,1]]},"reference":[{"key":"R1-20260505","doi-asserted-by":"crossref","first-page":"543","DOI":"10.2215\/CJN.03761106","article-title":"Pathophysiology of the clinical manifestations of preeclampsia","volume":"2","author":"Hladunewich","year":"2007","journal-title":"Clin J Am Soc Nephrol"},{"key":"R2-20260505","first-page":"4.","article-title":"Incidence of pregnancy induced hypertension and prescription pattern of antihypertensive drugs in pregnancy","volume":"23","author":"Sajith","year":"2014","journal-title":"Int J Pharm Sci Res"},{"key":"R3-20260505","doi-asserted-by":"crossref","first-page":"172808.","DOI":"10.5402\/2012\/172808","article-title":"Early detection of maternal risk for preeclampsia","volume":"2012","author":"Mikat","year":"2012","journal-title":"ISRN Obstet Gynecol"},{"key":"R4-20260505","first-page":"1122","article-title":"Hypertension in pregnancy. 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