{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:52:55Z","timestamp":1790977975463,"version":"4.1.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Diabetic Charcot neuroarthropathy (CN) is a limb-threatening complication of long-standing diabetes mellitus and is frequently complicated by secondary infection. India-specific data on the microbiological spectrum and antimicrobial susceptibility patterns of infections complicating diabetic CN are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This retrospective observational study included 82 adult patients with diabetic CN and associated foot ulcers. Deep tissue or ulcer-base samples were collected under aseptic precautions and processed for bacterial culture, organism identification, and antimicrobial susceptibility testing using standard microbiological methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Culture positivity was observed in 61 (74.4%) cases, with monomicrobial growth in 39 (47.6%) and polymicrobial growth in 18 (22.0%) cases. A total of 96 microbial isolates were identified. Gram-negative organisms predominated, accounting for 60\/96 (62.5%) bacterial isolates, while Gram-positive organisms constituted 34\/96 (35.4%). The most frequent isolates were\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      24 (25.0%), of which methicillin-resistant\n                      <jats:italic toggle=\"yes\">S<\/jats:italic>\n                      .\n                      <jats:italic toggle=\"yes\">aureus<\/jats:italic>\n                      accounted for 9 isolates, representing 37.5% of all\n                      <jats:italic toggle=\"yes\">S<\/jats:italic>\n                      .\n                      <jats:italic toggle=\"yes\">aureus<\/jats:italic>\n                      isolates, followed by\n                      <jats:italic toggle=\"yes\">Pseudomonas<\/jats:italic>\n                      <jats:italic toggle=\"yes\">aeruginosa<\/jats:italic>\n                      18 (18.75%),\n                      <jats:italic toggle=\"yes\">Escherichia<\/jats:italic>\n                      <jats:italic toggle=\"yes\">coli<\/jats:italic>\n                      16 (16.67%), and\n                      <jats:italic toggle=\"yes\">Klebsiella<\/jats:italic>\n                      <jats:italic toggle=\"yes\">pneumoniae<\/jats:italic>\n                      11 (11.46%). Fungal isolates were infrequent 2 (2.08%). Gram-positive organisms showed high sensitivity to linezolid (94.1%) and vancomycin (91.2%), whereas Gram-negative organisms were most sensitive to meropenem (80.0%) and piperacillin\u2013tazobactam (73.3%). Detailed characterization of extended-spectrum \u03b2-lactamase production and carbapenem resistance was not systematically performed in this retrospective dataset; however, the observed antimicrobial susceptibility patterns suggest the presence of clinically relevant multidrug resistance among Gram-negative organisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Infected diabetic CN in this Indian cohort demonstrated a predominance of Gram-negative pathogens with substantial polymicrobial infection and antimicrobial resistance. These findings highlight the importance of early, culture-guided, and region-specific antimicrobial strategies to optimize limb salvage outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aam.aam_83_26","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:00:22Z","timestamp":1790974822000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Common Pathogens Associated with Diabetic Charcot Neuroarthropathy in the Indian Population: A Retrospective Observational Study"],"prefix":"10.4103","author":[{"given":"Prashant","family":"Pawar","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Dr. D. Y. Patil Medical College and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya","family":"Bakshi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Dr. D. Y. Patil Medical College and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,5,14]]},"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_83_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:00:23Z","timestamp":1790974823000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_83_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,14]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/aam.aam_83_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,14]]},"assertion":[{"value":"2026-01-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}