{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:46:41Z","timestamp":1791812801464,"version":"4.3.4"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Phyllodes tumors are rare fibroepithelial neoplasms of the breast that typically exhibit benign or borderline behavior, with malignant transformation being an uncommon event. Even more exceptional is the occurrence of sarcomatous differentiation, particularly into osteosarcoma. We report the strikingly rare case of a 35-year-old female who initially presented with bilateral benign phyllodes tumors. Despite surgical excision and close follow-up, she developed a malignant transformation with osteosarcomatous features and widespread metastatic disease, including pulmonary and subcutaneous involvement. The aggressive course led to rapid clinical decline and ultimately, respiratory failure. This case underscores the unpredictable nature of phyllodes tumors and highlights the importance of vigilant, long-term monitoring \u2013 even in tumors initially diagnosed with benign. The transformation to an osteosarcomatous phenotype presents unique diagnostic and therapeutic challenges, reinforcing the need for a multidisciplinary approach and further research into tailored treatment options for such rare variants.<\/jats:p>","DOI":"10.4103\/aam.aam_8_26","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:00:10Z","timestamp":1780545610000},"page":"S549-S552","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case of Malignant Transformation in Bilateral Phyllodes Tumor Leading to Osteosarcomatous Metastases"],"prefix":"10.4103","volume":"25","author":[{"given":"Yogesh","family":"Langade","sequence":"first","affiliation":[{"name":"Department of General Surgery, Dr. D. Y. Patil Medical College, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishali","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Dr. D. Y. Patil Medical College, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhuri","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. D. Y. Patil Medical College, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charusheela R.","family":"Gore","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. D. Y. Patil Medical College, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronak","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Dr. D. Y. Patil Medical College, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"R1-20261012","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/his.12876","article-title":"Phyllodes tumours of the breast: A consensus review","volume":"68","author":"Tan","year":"2016","journal-title":"Histopathology"},{"key":"R2-20261012","doi-asserted-by":"crossref","first-page":"665","DOI":"10.5858\/arpa.2016-0042-RA","article-title":"Phyllodes tumor of the breast: Histopathologic features, differential diagnosis, and molecular\/genetic updates","volume":"140","author":"Zhang","year":"2016","journal-title":"Arch Pathol Lab Med"},{"key":"R3-20261012","doi-asserted-by":"crossref","first-page":"W173","DOI":"10.2214\/AJR.17.18554","article-title":"Phyllodes tumor of the breast: Ultrasound-pathology correlation","volume":"210","author":"Kalambo","year":"2018","journal-title":"AJR Am J Roentgenol"},{"key":"R4-20261012","first-page":"e37737","article-title":"Osteosarcoma originating from a malignant phyllodes tumor: A case report of a rare malignancy","volume":"15","author":"Jha","year":"2023","journal-title":"Cureus"},{"key":"R5-20261012","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s13193-022-01525-7","article-title":"Malignant phyllodes tumor with heterologous sarcomatous differentiation: A case series and review of literature","volume":"13","author":"Atram","year":"2022","journal-title":"Indian J Surg Oncol"},{"key":"R6-20261012","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.breast.2021.03.001","article-title":"Retrospective study of malignant phyllodes tumors of the breast: Younger age, prior fibroadenoma surgery, malignant heterologous elements and surgical margins may predict recurrence","volume":"57","author":"Li","year":"2021","journal-title":"Breast"},{"key":"R7-20261012","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s13193-015-0397-9","article-title":"Metastatic malignant phyllodes tumor of the breast: An aggressive disease-analysis of 7 cases","volume":"6","author":"Ramakant","year":"2015","journal-title":"Indian J Surg Oncol"},{"key":"R8-20261012","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/ccr3.1428","article-title":"Malignant transformation of phyllodes tumor: A case report and review of literature","volume":"6","author":"Pornchai","year":"2018","journal-title":"Clin Case Rep"},{"key":"R9-20261012","doi-asserted-by":"crossref","first-page":"1141353","DOI":"10.3389\/fmed.2023.1141353","article-title":"Case report: Osteosarcomatous differentiation in the lung metastasis of a malignant phyllodes tumor","volume":"10","author":"Liu","year":"2023","journal-title":"Front Med (Lausanne)"},{"key":"R10-20261012","doi-asserted-by":"crossref","first-page":"176","DOI":"10.18231\/j.jdpo.2024.037","article-title":"Malignant phyllodes tumour with osteosarcomatous and liposarcomatous elements \u2013 A rare entity","volume":"9","author":"Nair","year":"2024","journal-title":"IP J Diagn Pathol Oncol (Internet)"},{"key":"R11-20261012","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1016\/j.radcr.2023.05.074","article-title":"High grade phyllodes tumor with osteosarcomatous differentiation: Case report and review of the literature","volume":"18","author":"Hall","year":"2023","journal-title":"Radiol Case Rep"}],"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_8_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:01:21Z","timestamp":1791810081000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_8_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,3]]},"references-count":11,"journal-issue":{"issue":"Suppl 3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/aam.aam_8_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,3]]},"assertion":[{"value":"2026-01-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}