{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:28:45Z","timestamp":1787761725976,"version":"build-2784847793"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study was conducted to assess the efficacy of intravenous nitroglycerin versus dexmedetomidine in achieving controlled hypotension in patients with chronic rhinosinusitis during functional endoscopic sinus surgery (FESS), and to compare the effects of these drugs on hemodynamics, intraoperative analgesic requirement, surgical field quality, and recovery characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>This randomized study was conducted on 50 patients, randomly assigned into two groups: Group D (dexmedetomidine) and Group N (nitroglycerin). Mean arterial pressure (MAP) was maintained between 50 and 65 mmHg. Intraoperative hemodynamics, fentanyl requirement, extubation time, and surgical field (Boezaart scale) were recorded and statistically analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Group D showed significantly lower mean heart rates (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and reduced fentanyl requirement (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001). Group N achieved the target MAP faster and demonstrated shorter extubation times (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001). The quality of the surgical field and the duration of the surgery were comparable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Both the drugs used in our study are effective for controlling hypotension during FESS. Dexmedetomidine offers added analgesic-sparing benefits, while nitroglycerin allows faster recovery, making it preferable in cases requiring early extubation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aam.aam_9_26","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:22:49Z","timestamp":1781018569000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Efficacy of Intravenous Dexmedetomidine and Intravenous Nitroglycerin for Hypotensive Anesthesia in Patients Undergoing Functional Endoscopic Sinus Surgery: A Randomized Double-blind Prospective Study"],"prefix":"10.4103","author":[{"given":"Anuj","family":"Kayath","sequence":"first","affiliation":[{"name":"Department of Critical Care, Indraprastha Apollo Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmeet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Fortis Hospital, Mohali, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Rohilla","sequence":"additional","affiliation":[{"name":"Department of IVF and Human Reproduction, Sir Gangaram Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit K.","family":"Malviya","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,6,9]]},"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_9_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:05:27Z","timestamp":1787760327000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_9_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/aam.aam_9_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,9]]},"assertion":[{"value":"2026-01-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}