{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:19:57Z","timestamp":1787771997757,"version":"build-2784847793"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>At present, increasing evidence has reported circulating microRNAs (miRNAs) as potential clinical biomarkers for specific diseases and administration of pharmaceutical agents. The main aim of this study was to compare the effect of two selected home-based resistance exercise (HBRE) and game-based exercise training (GBET) groups on microRNA21-5p expression and biomarkers related to non-alcoholic fatty liver in children with type 1 diabetes (T1D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Twenty children with T1D aged 10\u201315 years were randomly assigned to one of two groups (HBRE: n = 10; GBET: n = 10). The exercise training lasted for 8 weeks with three sessions per week. The liver enzyme profile, hemoglobin A1c (HbA1c), glucose, microRNA-21-5p, insulin, and Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) levels were measured before and after the interventions in both groups. In addition, the cardiopulmonary fitness and body fat percentage (BF%) of the participants were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      After exercise interventions, miR-21-5p increased significantly for both intervention groups (HBRE: 8.9% vs. GBET: 6.7%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001). The levels of alanine transaminase (ALT) (HBRE: 60.71% vs. GBET: 49.15%) and aspartate aminotransferase (AST) enzymes (HBRE: 54.02% vs. GBET: 34.02%), the glucose (HBRE: 15.03% vs. GBET: 16.26%), and the HbA1c (HBRE: -10.44% vs. GBET: -6.52%) were decreased significantly (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.05). The cardiorespiratory endurance of subjects increased (HBRE: 2.85% vs. GBET: 3.75%), but there were no differences between groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2265 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Both HBRE and GBET protocols were effective to improve cardiorespiratory fitness, liver enzyme profile, glycemic control, and miR-21-5p changes that seem to be indicative of the pathological status of T1D children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_105_24","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T06:00:14Z","timestamp":1753941614000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["The Efficacy of Home-based Resistance Exercise and Game-based Exercise Training on microRNA-21-5p Expression and Non-Alcoholic Fatty Liver Biomarkers in Children with Type 1 Diabetes"],"prefix":"10.4103","volume":"14","author":[{"given":"Mohammed Kareem","family":"Yasir","sequence":"first","affiliation":[{"name":"Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vazgen","family":"Minasian","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silva","family":"Hovsepian","sequence":"additional","affiliation":[{"name":"Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahin","family":"Hashemipour","sequence":"additional","affiliation":[{"name":"Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7]]},"reference":[{"key":"R1-20250731","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S2213-8587(22)00218-2","article-title":"Global incidence, prevalence, and mortality of type 1 diabetes in 2021 with projection to 2040: A modelling study","volume":"10","author":"Gregory","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"key":"R2-20250731","doi-asserted-by":"crossref","first-page":"1031633","DOI":"10.3389\/fendo.2022.1031633","article-title":"Non-alcoholic fatty liver disease in type 1 diabetes: Prevalence and pathophysiology","volume":"13","author":"Memaj","year":"2022","journal-title":"Front 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