{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:29:52Z","timestamp":1792099792536,"version":"4.4.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study aimed to evaluate the efficacy of memantine in the acute treatment of geriatric with bipolar disorder (BD) hospitalized for mania.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      This study conducted on 70 patients older than 60 years with BD in the acute phase of mania. Oral sodium valproate was prescribed in both groups. The intervention group received memantine tablet and the placebo group received a placebo tablet based on a same procedure. Severity of mania, cognitive changes, and quality of life (QoL) were assessed and recorded 4 and 8 weeks after the beginning of the study. The collected data were analyzed with SPSS (version 20) using independent samples\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test, analysis of variance in repeated observations, Chi-squared test, and Fisher's exact test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mania severity score had no significant difference at the beginning of the study, but 4 and 8 weeks after the intervention, it was reduced significantly in both groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) that was higher in memantine group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.038). The mean increase in score of cognitive variations was 6.74 in the memantine group and 3.62 in the placebo group with a nonsignificant difference (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.125). The scores of each dimension of QoL in the two groups showed that in all four dimensions, the patient's physical, psychological, social, and environmental status increased significantly by time (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>According to the results of this study, memantine as an adjuvant to administration of sodium valproate may have a significant effect on decreasing the intensity of mania in the long run.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_110_18","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T01:54:28Z","timestamp":1543370068000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of the Effect of Memantine Supplementation in the Treatment of Acute Phase of Mania in Bipolar Disorder of Elderly Patients: A Double-blind Randomized Controlled Trial"],"prefix":"10.4103","volume":"7","author":[{"given":"Victoria","family":"Omranifard","sequence":"first","affiliation":[{"name":"From the Department of Psychiatry, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Javad","family":"Tarrahi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, Faculty of Health, Lorestan University of Medical Sciences, Khorramabad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shima","family":"Sharifi","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojgan","family":"Karahmadi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Isfahan University of Medical Sciences, Noor Hospital, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"R1-20251008","doi-asserted-by":"crossref","first-page":"e91936","DOI":"10.1371\/journal.pone.0091936","article-title":"The burden attributable to mental and substance use disorders as risk factors for suicide: Findings from the global burden of disease study 2010","volume":"9","author":"Ferrari","year":"2014","journal-title":"PLoS One"},{"key":"R2-20251008","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/S0140-6736(13)61611-6","article-title":"Global burden of disease attributable to mental and substance use disorders: Findings from the Global Burden of Disease Study 2010","volume":"382","author":"Whiteford","year":"2013","journal-title":"Lancet"},{"key":"R3-20251008","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1056\/NEJMsa043266","article-title":"Prevalence and treatment of mental disorders, 1990 to 2003","volume":"352","author":"Kessler","year":"2005","journal-title":"N Engl J Med"},{"key":"R4-20251008","first-page":"38","article-title":"Bipolar disorder in the elderly: Differential diagnosis and treatment","volume":"24","author":"Trinh","year":"2007","journal-title":"Psychiatr Times"},{"key":"R5-20251008","first-page":"191","article-title":"Glutamate receptor genes: Susceptibility factors in schizophrenia and depressive patients","volume":"25","author":"Shiffer","year":"2002","journal-title":"Mol Biol"},{"issue":"Suppl 10","key":"R6-20251008","first-page":"5","article-title":"Rationale for long-term treatment of bipolar disorder and evidence for long-term lithium treatment","volume":"63","author":"Goodwin","year":"2002","journal-title":"J Clin Psychiatry"},{"key":"R7-20251008","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.brainresrev.2009.06.003","article-title":"Bipolar disorder and mechanisms of action of mood stabilizers","volume":"61","author":"Rapoport","year":"2009","journal-title":"Brain Res Rev"},{"key":"R8-20251008","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/00019442-200504000-00006","article-title":"Maintenance treatment outcomes in older patients with bipolar I disorder","volume":"13","author":"Sajatovic","year":"2005","journal-title":"Am J Geriatr Psychiatry"},{"key":"R9-20251008","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jad.2016.03.034","article-title":"Acetylcholinesterase inhibitors and memantine in bipolar disorder: A systematic review and best evidence synthesis of the efficacy and safety for multiple disease dimensions","volume":"197","author":"Veronese","year":"2016","journal-title":"J Affect Disord"},{"key":"R10-20251008","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1176\/appi.ajp.162.7.1281","article-title":"Olanzapine versus lithium in the maintenance treatment of bipolar disorder: A 12-month, randomized, double-blind, controlled clinical trial","volume":"162","author":"Tohen","year":"2005","journal-title":"Am J Psychiatry"},{"key":"R11-20251008","doi-asserted-by":"crossref","first-page":"207","DOI":"10.5694\/j.1326-5377.2004.tb06238.x","article-title":"Major advances in bipolar disorder","volume":"181","author":"Mitchell","year":"2004","journal-title":"Med J Aust"},{"key":"R12-20251008","first-page":"1","article-title":"Efficacy of memantine as an adjuvant therapy in bipolar disorder; a double blind, randomized, clinical trial","volume":"21","author":"Bahrami Kalashgaran","year":"2016","journal-title":"Sci J Kurdistan Univ Med Sci"},{"key":"R13-20251008","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1056\/NEJMoa013128","article-title":"Memantine in moderate-to-severe Alzheimer's disease","volume":"348","author":"Reisberg","year":"2003","journal-title":"N Engl J Med"},{"key":"R14-20251008","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.neuroscience.2015.05.018","article-title":"The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders","volume":"300","author":"R\u00e9us","year":"2015","journal-title":"Neuroscience"},{"key":"R15-20251008","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/S0028-3908(02)00055-2","article-title":"Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats","volume":"42","author":"Rog\u00f3z","year":"2002","journal-title":"Neuropharmacology"},{"key":"R16-20251008","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.psychres.2010.12.030","article-title":"Memantine reduces mania-like symptoms in animal models","volume":"188","author":"Gao","year":"2011","journal-title":"Psychiatry Res"},{"key":"R17-20251008","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4103\/0019-5545.49455","article-title":"Memantine in the management of a clinically challenging case of bipolar disorder","volume":"51","author":"Agarwal","year":"2009","journal-title":"Indian J Psychiatry"},{"key":"R18-20251008","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/WNF.0b013e318184fae2","article-title":"Memantine efficacy and safety in patients with acute mania associated with bipolar I disorder: A pilot evaluation","volume":"32","author":"Keck","year":"2009","journal-title":"Clin Neuropharmacol"},{"key":"R19-20251008","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/gps.4375","article-title":"Combined treatment with memantine\/es-citalopram for older depressed patients with cognitive impairment: A pilot study","volume":"31","author":"Pelton","year":"2016","journal-title":"Int J Geriatr Psychiatry"},{"key":"R20-20251008","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jad.2011.09.040","article-title":"The sustained mood-stabilizing effect of memantine in the management of treatment resistant bipolar disorders: Findings from a 12-month naturalistic trial","volume":"136","author":"Koukopoulos","year":"2012","journal-title":"J Affect Disord"},{"key":"R21-20251008","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.4088\/JCP.13m08956","article-title":"Three-year, naturalistic, mirror-image assessment of adding memantine to the treatment of 30 treatment-resistant patients with bipolar disorder","volume":"76","author":"Serra","year":"2015","journal-title":"J Clin Psychiatry"},{"key":"R22-20251008","doi-asserted-by":"crossref","first-page":"80","DOI":"10.5498\/wjp.v4.i4.80","article-title":"Memantine: New prospective in bipolar disorder treatment","volume":"4","author":"Serra","year":"2014","journal-title":"World J Psychiatry"},{"key":"R23-20251008","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: Reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"Br J Psychiatry"},{"key":"R24-20251008","first-page":"150","article-title":"Standardization, validity and reliability of young mania rating scale in Iran","volume":"2","author":"Barakatain","year":"2007","journal-title":"J Psychol"},{"issue":"1","key":"R25-20251008","first-page":"14","article-title":"Psychometric Properties of the Persian Version of the Neuropsychiatry Unit Cognitive Assessment Tool (NUCOG) in Patients with Dementia","volume":"16","author":"Barekatain","year":"2010","journal-title":"Iranian Journal of Psychiatry and Clinical Psychology"},{"key":"R26-20251008","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1046\/j.1440-1665.2003.t01-1-00558.x","article-title":"The NUCOG: Construction and piloting of a cognitive screening instrument in a neuropsychiatric unit","volume":"11","author":"Walterfang","year":"2003","journal-title":"Australas Psychiatry"},{"key":"R28-20251008","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pcd.2011.02.001","article-title":"WHO quality of life-BREF 26 questionnaire: Reliability and validity of the Persian version and compare it with Iranian diabetics quality of life questionnaire in diabetic patients","volume":"5","author":"Jahanlou","year":"2011","journal-title":"Prim Care Diabetes"},{"key":"R29-20251008","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejphar.2015.01.041","article-title":"Memantine prevents \u201cbipolar-like\u201d behavior induced by chronic treatment with imipramine in rats","volume":"752","author":"Demontis","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"R30-20251008","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.pnpbp.2008.01.008","article-title":"A systematic review of off-label uses of memantine for psychiatric disorders","volume":"32","author":"Zdanys","year":"2008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"R31-20251008","doi-asserted-by":"crossref","first-page":"663","DOI":"10.2165\/11634390-000000000-00000","article-title":"The role of memantine in the treatment of psychiatric disorders other than the dementias: A review of current preclinical and clinical evidence","volume":"26","author":"Sani","year":"2012","journal-title":"CNS Drugs"},{"key":"R32-20251008","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1097\/JCP.0b013e31829b62ba","article-title":"Antimanic and long-lasting mood stabilizing effect of memantine in bipolar I mood disorder: Two case reports","volume":"33","author":"Serra","year":"2013","journal-title":"J Clin Psychopharmacol"},{"key":"R33-20251008","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/2045125313507737","article-title":"Memantine in the management of affective recurrences of bipolar disorders after the discontinuation of long-term lithium treatment: Three case histories","volume":"4","author":"Serra","year":"2014","journal-title":"Ther Adv Psychopharmacol"},{"key":"R34-20251008","first-page":"192","article-title":"Memantine in the treatment and prophylaxis of bipolar type II mood disorder and co-morbid eating disorder: A case report","volume":"49","author":"De Chiara","year":"2014","journal-title":"Riv Psichiatr"},{"key":"R35-20251008","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1399-5618.2011.00971.x","article-title":"Early antidepressant effect of memantine during augmentation of lamotrigine inadequate response in bipolar depression: A double-blind, randomized, placebo-controlled trial","volume":"14","author":"Anand","year":"2012","journal-title":"Bipolar Disord"},{"key":"R36-20251008","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.jpsychires.2013.06.017","article-title":"Add-on memantine to valproate treatment increased HDL-C in bipolar II disorder","volume":"47","author":"Lee","year":"2013","journal-title":"J Psychiatr Res"},{"key":"R37-20251008","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4088\/JCP.v67n0207","article-title":"Health-related quality of life and functioning of middle-aged and elderly adults with bipolar disorder","volume":"67","author":"Depp","year":"2006","journal-title":"J Clin Psychiatry"},{"key":"R38-20251008","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1185\/030079903125002801","article-title":"A systematic review evaluating health-related quality of life, work impairment, and healthcare costs and utilization in bipolar disorder","volume":"20","author":"Dean","year":"2004","journal-title":"Curr Med Res Opin"},{"key":"R39-20251008","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0025-7125(05)70334-5","article-title":"Bipolar disorder","volume":"85","author":"Keck","year":"2001","journal-title":"Med Clin North Am"}],"container-title":["Advanced Biomedical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01679891-201807000-00148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:29:53Z","timestamp":1786735793000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01679891-201807000-00148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.4103\/abr.abr_110_18","relation":{},"ISSN":["2277-9175"],"issn-type":[{"value":"2277-9175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2018-06-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-01","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}