{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:23:05Z","timestamp":1787847785342,"version":"build-2784847793"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"\n Background:<\/jats:title>\n Human T-cell leukemia virus type 1(HTLV-1) infection is likely to induce nonneoplastic inflammatory pulmonary diseases. Therefore, an experimental study was conducted to evaluate the leukocytes' number alteration and oxidative stress in the lung and blood of HTLV-1-infected BALB\/c mice, which could be of benefit for the recognition of HTLV-1 mechanism in the induction of pulmonary disorders.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Twenty female BALB\/c mice were divided into two groups of control and HTLV-1-infected animals. The HTLV-1-infected group was inoculated with 10\n 6<\/jats:sup>\n MT-2 HTLV-1-infected cells. Two months later, the infection was confirmed using real-time polymerase chain reaction, and then lung pathological changes, total and differential inflammatory cell counts in the blood and bronchoalveolar lavage fluid (BALF), along with oxidative stress biomarker levels in the BALF and lung tissue were evaluated.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n In the HTLV-1-infected group, the peribronchitis score (\n P<\/jats:italic>\n < 0.01), the number of total leukocytes, neutrophils, lymphocytes, and monocytes (\n P<\/jats:italic>\n < 0.05) in the blood and BALF were increased. The number of eosinophils in the blood of the HTLV-1-infected group was higher than in the control group (\n P<\/jats:italic>\n < 0.01), whereas the number of basophils of BALF was increased in the HTLV-1-infected group (\n P<\/jats:italic>\n < 0.001). The lung and BALF oxidative stress results showed that the MDA level was increased, while the total thiol level and superoxide dismutase activity were decreased in the HTLV-1-infected group (\n P<\/jats:italic>\n < 0.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The HTLV-1 infection seems to induce pulmonary inflammatory reactions by recruiting leukocytes as well as inducing oxidative stress in the lung tissue.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/abr.abr_117_20","type":"journal-article","created":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T00:14:17Z","timestamp":1611965657000},"page":"6","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Human T-Cell Leukemia Virus Type 1 Changes Leukocyte Number and Oxidative Stress in the Lung and Blood of Female BALB\/c Mice"],"prefix":"10.4103","volume":"10","author":[{"given":"Mahdiyeh","family":"Hedayati-Moghadam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A. Rahim","family":"Rezaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hossein","family":"Boskabady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nema","family":"Mohamadian Roshan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeideh","family":"Saadat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kowsar","family":"Bavarsad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Niazmand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20240830","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/jmv.24448","article-title":"Prevalence and phylogenetic analysis of HTLV-1 in a segregated population in Iran","volume":"88","author":"Rafatpanah","year":"2016","journal-title":"J Med Virol"},{"key":"R2-6-20240830","first-page":"179","article-title":"Human T lymphotropic virus type I (HTLV-I) oncogenesis: Molecular aspects of virus and host interactions in Pathogenesis of Adult T cell Leukemia\/Lymphoma (ATL)","volume":"16","author":"Ahmadi Ghezeldasht","year":"2013","journal-title":"Iran J Basic Med Sci"},{"key":"R3-6-20240830","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.3389\/fmicb.2018.01879","article-title":"Lymphotropic virus and pulmonary diseases","volume":"9","author":"Dias","year":"2018","journal-title":"Front Microbiol"},{"key":"R4-6-20240830","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.2169\/internalmedicine.54.4717","article-title":"Human T-cell Lymphotropic virus type-1 (HTLV-1)-associated bronchioloalveolar disorder presenting with mosaic perfusion","volume":"54","author":"Yamakawa","year":"2015","journal-title":"Intern Med"},{"key":"R5-6-20240830","doi-asserted-by":"crossref","first-page":"130","DOI":"10.5692\/clinicalneurol.51.130","article-title":"[Rapid progressive HTLV-1-associated myelopathy with bronchoalveolar lesions and a long spinal cord lesion extending to almost the entire spinal cord]","volume":"51","author":"Itami","year":"2011","journal-title":"Rinsho Shinkeigaku"},{"key":"R6-6-20240830","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/00063198-199803000-00007","article-title":"Chronic bronchioloalveolitis associated with human T-cell lymphotrophic virus type I infection","volume":"4","author":"Sugimoto","year":"1998","journal-title":"Curr Opin Pulm Med"},{"key":"R7-6-20240830","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1183\/09031936.06.00131805","article-title":"Diffuse panbronchiolitis","volume":"28","author":"Poletti","year":"2006","journal-title":"Eur Respir J"},{"key":"R8-6-20240830","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1378\/chest.124.6.2283","article-title":"High expression of p40tax and pro-inflammatory cytokines and chemokines in the lungs of human T-lymphotropic virus type 1-related bronchopulmonary disorders","volume":"124","author":"Yamazato","year":"2003","journal-title":"Chest"},{"key":"R9-6-20240830","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1164\/ajrccm.160.3.9808125","article-title":"Induction of lymphocytic inflammatory changes in lung interstitium by human T lymphotropic virus type I","volume":"160","author":"Kawakami","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"R10-6-20240830","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4149\/av_2015_02_199","article-title":"Serum total antioxidant capacity status of HTLV-1 infected patients","volume":"59","author":"Shomali","year":"2015","journal-title":"Acta Virol"},{"key":"R11-6-20240830","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.lfs.2018.09.031","article-title":"HTLV-1 infection-induced motor dysfunction, memory impairment, depression, and brain tissues oxidative damage in female BALB\/c mice","volume":"212","author":"Hedayati Moghadam","year":"2018","journal-title":"Life Sci"},{"key":"R12-6-20240830","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.virol.2018.02.010","article-title":"The human T-cell leukemia virus type-1 p30 II protein activates p53 and induces the TIGAR and suppresses oncogene-induced oxidative stress during viral carcinogenesis","volume":"518","author":"Romeo","year":"2018","journal-title":"Virology"},{"key":"R13-6-20240830","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1164\/rccm.200501-017PP","article-title":"Oxidative stress in pulmonary fibrosis: A possible role for redox modulatory therapy","volume":"172","author":"Kinnula","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"R14-6-20240830","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1378\/chest.125.4.1239","article-title":"Clinical similarities and differences between human T-cell lymphotropic virus type 1-associated bronchiolitis and diffuse panbronchiolitis","volume":"125","author":"Kadota","year":"2004","journal-title":"Chest"},{"key":"R15-6-20240830","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1046\/j.1365-2249.2000.01237.x","article-title":"Up-regulation of human T lymphotropic virus type 1 (HTLV-1) tax\/rex mRNA in infected lung tissues","volume":"120","author":"Seki","year":"2000","journal-title":"Clin Exp Immunol"},{"key":"R16-6-20240830","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1136\/thx.2004.021667","article-title":"Bronchoalveolar lymphocytosis correlates with human T lymphotropic virus type I (HTLV-I) proviral DNA load in HTLV-I carriers","volume":"60","author":"Mori","year":"2005","journal-title":"Thorax"},{"key":"R17-6-20240830","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/294770a0","article-title":"Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells","volume":"294","author":"Miyoshi","year":"1981","journal-title":"Nature"},{"key":"R18-6-20240830","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","article-title":"Determination of malonaldehyde precursor in tissues by thiobarbituric acid test","volume":"86","author":"Mihara","year":"1978","journal-title":"Anal Biochem"},{"key":"R19-6-20240830","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","article-title":"Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent","volume":"25","author":"Sedlak","year":"1968","journal-title":"Anal Biochem"},{"key":"R20-6-20240830","first-page":"184","article-title":"Microtiter plate assay for superoxide dismutase using MTT reduction by superoxide","volume":"35","author":"Madesh","year":"1998","journal-title":"Indian J Biochem Biophys"},{"key":"R22-6-20240830","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1002\/ptr.5429","article-title":"The protective effect of \u03b1-Hederin, the active constituent of Nigella sativa, on lung inflammation and blood cytokines in ovalbumin sensitized guinea pigs","volume":"29","author":"Keyhanmanesh","year":"2015","journal-title":"Phytother Res"},{"key":"R23-6-20240830","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12931-018-0754-7","article-title":"Evaluation of oxidative stress biomarkers in idiopathic pulmonary fibrosis and therapeutic applications: A systematic review","volume":"19","author":"Fois","year":"2018","journal-title":"Respir Res"},{"key":"R24-6-20240830","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.2174\/138161211798357728","article-title":"Intracellular redox signaling as therapeutic target for novel antiviral strategy","volume":"17","author":"Nencioni","year":"2011","journal-title":"Curr Pharm Des"},{"key":"R25-6-20240830","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1423-0127-16-61","article-title":"Total antioxidant capacity-a novel early bio-chemical marker of oxidative stress in HIV infected individuals","volume":"16","author":"Suresh","year":"2009","journal-title":"J Biomed Sci"},{"key":"R26-6-20240830","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1182\/blood-2013-03-493718","article-title":"HTLV-1 Tax oncoprotein stimulates ROS production and apoptosis in T cells by interacting with USP10","volume":"122","author":"Takahashi","year":"2013","journal-title":"Blood"},{"key":"R27-6-20240830","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/j.freeradbiomed.2011.07.023","article-title":"HIV-1 Tat increases oxidant burden in the lungs of transgenic mice","volume":"51","author":"Cota-Gomez","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"R28-6-20240830","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/pin.12030","article-title":"Lung miliary micro-nodules in human T-cell leukemia virus type I carriers","volume":"63","author":"Fukuoka","year":"2013","journal-title":"Pathol Int"},{"key":"R29-6-20240830","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2466-3-1","article-title":"Pulmonary function testing in HTLV-I and HTLV-II infected humans: A cohort study","volume":"3","author":"Murphy","year":"2003","journal-title":"BMC Pulm Med"},{"key":"R30-6-20240830","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1136\/jcp.24.1.72","article-title":"Bronchiolitis obliterans, bronchiectasis, and other sequelae of adenovirus type 21 infection in young children","volume":"24","author":"Becroft","year":"1971","journal-title":"J Clin Pathol"},{"key":"R31-6-20240830","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s00277-002-0465-4","article-title":"KL-6 as an indicator for lymphocytic interstitial pneumonia (LIP) in a human T-lymphotrophic virus type 1 (HTLV-1) carrier","volume":"81","author":"Ishikawa","year":"2002","journal-title":"Ann Hematol"},{"key":"R32-6-20240830","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1148\/radiol.2402050886","article-title":"Pulmonary CT findings in 320 carriers of human T-lymphotropic virus type 1","volume":"240","author":"Okada","year":"2006","journal-title":"Radiology"},{"key":"R33-6-20240830","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1440-1843.2009.01646.x","article-title":"Multiple tiny granulomatous lesions with eosinophils in a patient with smoldering-type adult T-cell leukaemia: The possibility of a new type of bronchioloalveolopathy","volume":"15","author":"Ishii","year":"2010","journal-title":"Respirology"},{"key":"R34-6-20240830","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1007\/s00268-006-0730-0","article-title":"Current update on HIV-associated vascular disease and endothelial dysfunction","volume":"31","author":"Mu","year":"2007","journal-title":"World J Surg"},{"key":"R35-6-20240830","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s00018-008-7526-3","article-title":"Transient cytoskeletal alterations after SOD1 depletion in neuroblastoma cells","volume":"65","author":"Vigilanza","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"R36-6-20240830","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1365-2249.1994.tb06541.x","article-title":"Expression of human T lymphotropic virus type 1 (HTLV-1) tax\/rex gene in fresh bronchoalveolar lavage cells of HTLV-1-infected individuals","volume":"96","author":"Higashiyama","year":"1994","journal-title":"Clin Exp Immunol"},{"key":"R37-6-20240830","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1046\/j.1365-2249.1999.01093.x","article-title":"Elevated levels of \u03b2-chemokines in bronchoalveolar lavage fluid (BALF) of individuals infected with human T lymphotropic virus type-1 (HTLV-1)","volume":"118","author":"Seki","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"R39-6-20240830","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.leukres.2006.10.017","article-title":"Clinical significance of a blood eosinophilia in adult T-cell leukemia\/lymphoma: A blood eosinophilia is a significant unfavorable prognostic factor","volume":"31","author":"Utsunomiya","year":"2007","journal-title":"Leuk Res"},{"key":"R40-6-20240830","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1002\/1097-0142(19881015)62:8<1527::AID-CNCR2820620813>3.0.CO;2-X","article-title":"Eosinophilia associated with adult T-cell leukemia\/lymphoma","volume":"62","author":"Vukelja","year":"1988","journal-title":"Cancer"}],"container-title":["Advanced Biomedical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/abr.abr_117_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:37:55Z","timestamp":1787845075000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/abr.abr_117_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/abr.abr_117_20","relation":{},"ISSN":["2277-9175"],"issn-type":[{"value":"2277-9175","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}