{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:23:04Z","timestamp":1787847784942,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Methicillin-resistant\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      (MRSA) has become a considerable public health concern in the entire world due to the rapid spread of this bacterium in human community; also the epidemiology of MRSA has changed, as the isolation of MRSA strains from healthy and non-healthy patients. Therefore, the objective of this study is to determine the genetic diversity and antibiotic resistance profile of community-acquired (CA)-MRSA nasal carriage in the Iranian samples.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 25 CA-MRSA were isolated from the anterior nares of 410 healthy preschool children. All MRSA isolates were characterized by the detection of the toxic shock syndrome toxin-1 (TSST-1) and typed by \u03b3-hemolysin genes,\n                      <jats:italic toggle=\"yes\">agr<\/jats:italic>\n                      groups, and staphylococcal protein A (\n                      <jats:italic toggle=\"yes\">spa<\/jats:italic>\n                      ) typing. Kirby-Buyer antibiotic susceptibility testing was performed and interpreted as per the standard guidelines.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 25 (6.1%) MRSA isolates were recovered from the anterior nares of 410 preschool children. Sixteen isolates (64%) were positive for the TSST-1 gene. Three\n                      <jats:italic toggle=\"yes\">agr<\/jats:italic>\n                      specificity groups were determined, as follows: eight (32%) isolates belonged to\n                      <jats:italic toggle=\"yes\">agr<\/jats:italic>\n                      Group I, five (20%) isolates belonged to\n                      <jats:italic toggle=\"yes\">agr<\/jats:italic>\n                      Group II, and 12 (48%) isolates belonged to\n                      <jats:italic toggle=\"yes\">agr<\/jats:italic>\n                      Group III. The repeated profiles of these\n                      <jats:italic toggle=\"yes\">spa<\/jats:italic>\n                      types of 25 isolates were organized into eight different lineages groups. Five of lineages contained a single strain, three of lineages contained two strains, and three of lineages consisted of more than three strains.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      The results of our study show that the rate of MRSA in our region is significantly high. Additionally,\n                      <jats:italic toggle=\"yes\">spa<\/jats:italic>\n                      type t037 was the predominant type among CA\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_139_20","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T04:14:11Z","timestamp":1611720851000},"page":"3","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Typing of Community-acquired Methicillin-Resistant Staphylococcus aureus Isolated from 2- to 6-year old Children by Staphylococcal Protein A and Agr Typing in Isfahan, 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