{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:07:09Z","timestamp":1792192029817,"version":"4.4.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1]]},"abstract":"\n Background:<\/jats:title>\n Polycystic ovarian syndrome (PCOS) is an endocrine disorder in fertile women, which seems to be adversely affected by associated thyroid dysfunction. Zinc methionine (ZM) has positive effects on PCOS, but its concerted effects on PCOS and thyroid function have not been investigated. We evaluated the effects of ZM on reproductive and thyroid hormones and the number of follicles in rats with PCOS.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n This study was conducted on 45 female rats, using sesame oil as control; PCOS animals administered with 0, 25, 75, and 175 mg\/kg BW of ZM. Serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and thyroid function were investigated. Premature follicles (PMF), primary follicles (PF), preantral follicles (PAF), antral follicles (AF), corpus luteum (CL), and cystic follicles (CF) were assessed.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n PCOS decreased the concentrations of FSH and free T4, but increased the levels of LH, TSH, and LH\/FSH ratio (ALL\n P<\/jats:italic>\n < 0.05). ZM at a dose of 75 and 175 mg increased the level of FSH, free T4, and decreased LH, TSH, and LH\/FSH ratio (ALL\n P<\/jats:italic>\n < 0.05). Induction of PCOS decreased PMF, PF, PAF, AF, and CL, but increased CF (\n P<\/jats:italic>\n < 0.05). PCOS treated groups (75 and 175 mg\/kg) increased these follicle numbers and decreased CF compared to ZM 25 mg\/kg and PCOS groups (Both\n P<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Although the induction of PCOS had a negative effect on reproductive and thyroid hormones and follicle numbers, ZM treatment (75 and 175 mg\/kg) overcame the negative effects. A high dosage of ZM can alleviate the hormonal and cysts disturbances occurring in PCOS.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/abr.abr_144_20","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T05:35:21Z","timestamp":1604295321000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["The Effects of Zinc Methionine on Reproductive and Thyroid Hormones in Rats with Polycystic Ovarian Syndrome"],"prefix":"10.4103","volume":"9","author":[{"given":"Faeze","family":"Fazel Torshizi","sequence":"first","affiliation":[{"name":"Department of Animal Science, Science and Research Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Chamani","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Science and Research Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid Reza","family":"Khodaei","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, Islamic Azad University, Golpayegan Branch, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Asghar","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Science and Research Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Hossein","family":"Hejazi","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Mycology, Skin Disease and Leishmaniasis Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza Majidzadeh","family":"Heravi","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, Ferdowsi University of Mashhad, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"R1-20250805","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1055\/a-1073-2346","article-title":"Dynamic analysis of the biochemical changes in rats with polycystic ovary syndrome (PCOS) using urinary 1H NMR-based metabonomics","volume":"52","author":"Huang","year":"2020","journal-title":"Horm Metab Res"},{"key":"R2-20250805","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3389\/fendo.2020.00144","article-title":"Transgenerational inheritance of reproductive and metabolic phenotypes in PCOS rats","volume":"11","author":"Zhang","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"R3-20250805","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4103\/2230-8210.109714","article-title":"Thyroid disorders in polycystic ovarian syndrome subjects: A tertiary hospital based cross-sectional study from Eastern India","volume":"17","author":"Sinha","year":"2013","journal-title":"Indian J Endocrinol Metab"},{"key":"R4-20250805","first-page":"89","article-title":"The Mechanism of Androgen Actions in PCOS Etiology","volume":"7","author":"Rodriguez Paris","year":"2019","journal-title":"Med Sci (Basel)"},{"key":"R5-20250805","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1210\/js.2019-00078","article-title":"Polycystic ovary syndrome: Pathophysiology, presentation, and treatment with emphasis on adolescent girls","volume":"3","author":"Witchel","year":"2019","journal-title":"J Endocr Soc"},{"key":"R6-20250805","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.tem.2016.11.008","article-title":"Oocyte competence in women with polycystic ovary syndrome","volume":"28","author":"Palomba","year":"2017","journal-title":"Trends Endocrinol Metab"},{"key":"R7-20250805","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12902-019-0486-9","article-title":"PCOS without hyperandrogenism is associated with higher plasma trimethylamine N-oxide levels","volume":"20","author":"Huang","year":"2020","journal-title":"BMC Endocr Disord"},{"key":"R8-20250805","doi-asserted-by":"crossref","first-page":"197","DOI":"10.18576\/jpac\/020310","article-title":"The relation between hypothyroidism and polycystic ovary syndrome","volume":"2","author":"Elslimani","year":"2016","journal-title":"J Pharm Appl Chem"},{"key":"R9-20250805","first-page":"265","article-title":"Does the thyroid hormonal levels alter in polycystic ovarian disease. 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