{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:23:39Z","timestamp":1787840619262,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effects of different doses of dexmedetomidine and propofol on sedation, hemodynamic changes, and postoperative complications in patients undergoing ovarian puncture surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This randomized controlled trial was conducted on 96 women candidates for ovarian puncture surgery. In the first group (DEX-0.5), a bolus dose of dexmedetomidine 0.5 \u00b5g\/kg was administered for the induction of anesthesia, followed by a maintenance dose of dexmedetomidine 0.5 \u00b5g\/kg\/min. In the second group (DEX-1), a bolus dose of dexmedetomidine 1 \u00b5g\/kg was administered for induction, followed by a maintenance dose of dexmedetomidine 1 \u00b5g\/kg\/min. In the third group (control group), propofol 50 \u00b5g\/kg\/min was administered for induction of anesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      SBP, DBP, and MAP were significantly lower in the control group compared to the other groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value &lt; 0.05). The mean scores of patient and surgical satisfaction levels in the DEX-0.5 group were significantly higher than the control group (4.00 \u00b1 1.02 and 4.41 \u00b1 0.57, respectively) and in the DEX-1 group (6.00 \u00b1 1.35 and 4.61 \u00b1 0.56, respectively) compared to the control group (2.90 \u00b1 2.10 and 3.10 \u00b1 0.32, respectively) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value &lt; 0.05). Need for additional analgesics was significantly higher in the control group compared to the intervention groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>It seems that the administration of dexmedetomidine 1 \u00b5g\/kg, due to better pain relief, higher satisfaction, less need for additional analgesics, and minimal occurrence of complications, can be recommended as a safe and effective dose in ovarian puncture surgery.<\/jats:p>\n                  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