{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:34:29Z","timestamp":1787758469917,"version":"build-2784847793"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"\n Background:<\/jats:title>\n \n Considering the side effects of common drugs used to treat polycystic ovary syndrome (PCOS), researchers have turned their attention to natural compounds, including medicinal plants.\n Foeniculum vulgare<\/jats:italic>\n has estrogenic properties and has been traditionally used to treat gynecological disorders.\n Bunium persicum<\/jats:italic>\n has medical aspects that have not yet been evaluated, so the aim of this study was to evaluate the effects of combination therapy with these extracts on clinical symptoms of women with PCOS.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n In this double-blind clinical trial study, 70 women with PCOS referred to infertility clinics, were selected and randomly divided into two groups. The intervention group received\n B. persicum<\/jats:italic>\n capsule 60 mg plus\n F. vulgare<\/jats:italic>\n capsule 25 mg) twice daily for 4 months and the control groups received routine intervention. Before and after the intervention, levels of luteinizing hormone (LH), follicle-stimulating hormone, progesterone, prolactin, testosterone and dehydroepiandrosterone sulfate (DHEAS) levels, hirsutism score, and menstrual pattern were recorded and endometrial thickness and follicle count were determined by ultrasound. Data were analyzed by the SPSS21 software.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Treatment with\n B. persicum<\/jats:italic>\n and\n F. vulgare<\/jats:italic>\n extracts significantly decreased LH and DHEAS levels, hirsutism score, and significantly increased menstrual duration compared to the control group. Before the intervention, 5.7% of the intervention and control groups had the normal menstrual pattern, while after the intervention 31.4% of the intervention group and 25.7% of the control group had the normal pattern.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Regarding the effect of these extracts combination and because they have no side-effects, which is a great advantage over chemical drugs, using of these plants recommend.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/abr.abr_163_21","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T06:23:33Z","timestamp":1664173413000},"page":"74","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Effects of Combination Therapy with Bunium persicum and Foeniculum vulgare Extracts on Patients with Polycystic Ovary Syndrome"],"prefix":"10.4103","volume":"11","author":[{"given":"Fatemeh","family":"Aliakbari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misa","family":"Naghdipour Mirsadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmira","family":"Hashemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Rahimi-Madiseh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belgheis","family":"Mohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-74-20240830","doi-asserted-by":"crossref","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic ovary syndrome","volume":"2","author":"Azziz","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"R2-74-20240830","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/humrep\/det469","article-title":"The prevalence of polycystic ovary syndrome in a normal population according to the Rotterdam criteria versus revised criteria including anti-M\u00fcllerian hormone","volume":"29","author":"Lauritsen","year":"2014","journal-title":"Human Reprod"},{"key":"R3-74-20240830","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1477-7827-9-39","article-title":"The prevalence of polycystic ovary syndrome in a community sample of Iranian population: Iranian PCOS prevalence study","volume":"9","author":"Tehrani","year":"2011","journal-title":"Reprod Biol Endocrinol"},{"key":"R4-74-20240830","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.bpobgyn.2004.05.007","article-title":"Hirsutism and acne in polycystic ovary syndrome","volume":"18","author":"Archer","year":"2004","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"R5-74-20240830","first-page":"305","article-title":"PCOS and infertility","volume":"50","author":"Hart","year":"2008","journal-title":"Panminerva Med"},{"key":"R6-74-20240830","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMcp1514916","article-title":"Clinical practice. 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