{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:33:20Z","timestamp":1793237600453,"version":"4.5.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Prevalent parasite infection,\n                      <jats:italic toggle=\"yes\">Ascaris lumbricoides<\/jats:italic>\n                      affects millions of people globally, especially in inadequate sanitation and hygiene. Swallowing\n                      <jats:italic toggle=\"yes\">A<\/jats:italic>\n                      .\n                      <jats:italic toggle=\"yes\">lumbricoides<\/jats:italic>\n                      eggs from contaminated food, water, or soil causes infection. This study examines age-related differences in interleukin levels and immunological response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      In this cross-sectional study, the samples were collected from\n                      <jats:italic toggle=\"yes\">A<\/jats:italic>\n                      .\n                      <jats:italic toggle=\"yes\">lumbricoides<\/jats:italic>\n                      -infected persons diagnosed by a general stool examination and divided into six age groups. The study comprised 180 samples from Al-Habbobi and Al-Nassiriya teaching hospitals and private clinics across six age groups. The control group had 90 worm-free samples. Forty samples were removed for not meeting the research criteria. The study assessed C-reactive protein (CRP), IL4, IL5, and TNF-a by ELISA and WBC count by Sysmex CBC. Anova, Mann\u2013Whitney, and\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -tests showed biological indicator differences between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Significant increases in CRP, WBC, Interleukin-4, and Interleukin-5 were observed in all study groups across 6 age groups compared to the control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.01). TNF levels decreased significantly in the first group compared to the control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.01), but they increased significantly in the other groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The high number of white blood cells indicates the presence of inflammation. In addition, high CRP levels indicate the severity of the infection caused by the parasite. Because of the immune response carried out by the immune system as a means of defense against the parasite, this leads to high levels of interleukin-4, interleukin-5 and TNF-alpha.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_172_24","type":"journal-article","created":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:00:08Z","timestamp":1793210408000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Differences in Immunological and Inflammatory Biomarkers Levels in People Infected with Ascaris lumbricoides according to Different Age Groups"],"prefix":"10.4103","volume":"15","author":[{"given":"Zainab Naser","family":"Al-Laith","sequence":"first","affiliation":[{"name":"Department of Biology, College of Science, University of Kerbala, Kerbala, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aseel 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