{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:46:32Z","timestamp":1787071592939,"version":"build-2736575974"},"reference-count":102,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Gastric cancer (GC) represents a global healthcare challenge. Recently, many competing endogenous RNA (ceRNA) network studies have elucidated critical long noncoding RNAs (lncRNAs) as potential prognostic biomarkers in GC. Since there is no systematic review and meta-analysis regarding the lncRNAs as ceRNA in GC, we propose the current study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      The Web of Science, Embase, PubMed, Scopus, ProQuest, and Google Scholar databases were searched to collect eligible ceRNA network studies in which lncRNAs were reported as prognostic biomarkers until 20\n                      <jats:sup>th<\/jats:sup>\n                      September 2024. Prognostic values of highly reported lncRNAs were examined. Furthermore, sensitivity analysis, and publication bias were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Totally, 56 studies were included in the systematic review. Based on these studies, the association of 350 unique lncRNAs with overall survival of GC patients were evaluated. 28 studies were eligible for meta-analysis. Four lncRNAs including\n                      <jats:italic toggle=\"yes\">ADAMTS9-AS2<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">AL391152.1<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">CCDC144NL-AS1<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">PVT1<\/jats:italic>\n                      were the most reported prognostic biomarkers. Meta-analysis confirmed the prognostic effect of\n                      <jats:italic toggle=\"yes\">CCDC144NL-AS1<\/jats:italic>\n                      (hazard ratio (HR) = 1.577 (95% confidence interval (CI): 1.382-1.801) in GC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Our meta-analysis demonstrated potential application of lncRNA\n                      <jats:italic toggle=\"yes\">CCDC144NL-AS1<\/jats:italic>\n                      based on the ceRNA network studies as a promising prognostic biomarker in GC. Further studies are needed to elucidate the functions of this lncRNA in GC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>The review protocol was registered on The International Prospective Register of Systematic Reviews (PROSPERO) (CRD42022360864).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_185_25","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T20:00:13Z","timestamp":1764532813000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Competing Endogenous RNA Networks Reveal Long Non-coding RNAs as Potential Prognostic Biomarkers in Gastric Cancer: A Systematic Review and Meta-Analysis"],"prefix":"10.4103","volume":"14","author":[{"given":"Sadra","family":"Salehi-Mazandarani","sequence":"first","affiliation":[{"name":"Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hossein","family":"Donyavi","sequence":"additional","affiliation":[{"name":"Biodesign Institute Center for Mechanisms of Evolution, Arizona State University, Tempe, Arizona, United States"},{"name":"School of Life Sciences, Arizona State University, Temp, Arizona, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Vedaei","sequence":"additional","affiliation":[{"name":"Dental Materials Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Najimi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziba","family":"Farajzadegan","sequence":"additional","affiliation":[{"name":"Department of Community and Family Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvaneh","family":"Nikpour","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran"},{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, 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