{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:25:18Z","timestamp":1787775918699,"version":"build-2784847793"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>An 81-year-old female presented with a loss of consciousness and a history of fever, dry cough, dyspnea, and conjunctivitis during 5 days ago. On initial physical examination, the laboratory examination revealed high levels of lactate dehydrogenase and creatinine concomitant severe thrombocytopenia. Moreover, the peripheral blood smear showed schistocytes 3%, suggesting thrombotic thrombocytopenic purpura (TTP). A ground-glass pattern was reported in the high-resolution computed tomography of the lung. A positive polymerase chain reaction was reported for coronavirus disease 2019 (COVID-19). After initiating treatment for COVID-19, the patient received fresh frozen plasma and 24-h electrocardiogram monitoring in the emergency department. As the patient was being prepared for transfer to another hospital for plasmapheresis treatment, cardiac arrest occurred again, and the patient passed away. This study highlights the atypical behavior of this virus over the course of the disease including TTP with conjunctivitis, which could vary from case to case.<\/jats:p>","DOI":"10.4103\/abr.abr_190_20","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T05:50:57Z","timestamp":1606542657000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Thrombotic Thrombocytopenic Purpura with Conjunctivitis in a Patient with Coronavirus Disease 2019 Infection"],"prefix":"10.4103","volume":"9","author":[{"given":"Gholamali","family":"Dorooshi","sequence":"first","affiliation":[{"name":"Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar Sadat","family":"Lalehzar","sequence":"additional","affiliation":[{"name":"Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Nasri","sequence":"additional","affiliation":[{"name":"Grovemead Health Center, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rokhsareh","family":"Meamar","sequence":"additional","affiliation":[{"name":"Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,11,28]]},"reference":[{"key":"R1-20250805","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0140-6736(20)30185-9","article-title":"A novel coronavirus outbreak of global health concern","volume":"395","author":"Wang","year":"2020","journal-title":"Lancet"},{"key":"R2-20250805","year":"2020","journal-title":"Coronavirus Disease 2019 (COVID-19): Situation Report, 72 World Health Organization"},{"key":"R3-20250805","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1111\/all.14238","article-title":"Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China","volume":"75","author":"Zhang","year":"2020","journal-title":"Allergy"},{"key":"R4-20250805","doi-asserted-by":"crossref","first-page":"153","DOI":"10.31584\/jhsmr.2020733","article-title":"Uncommon atypical presentations of COVID-19: Important and should not be under recognized!","volume":"38","author":"Tin","year":"2020","journal-title":"J Health Sci Med Res"},{"key":"R5-20250805","first-page":"E131","article-title":"Hematologic parameters in patients with COVID-19 infection","volume":"95","author":"Fan","year":"2020","journal-title":"Am J Hematol"},{"key":"R6-20250805","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s00277-020-04019-0","article-title":"Mechanism of thrombocytopenia in COVID-19 patients","volume":"99","author":"Xu","year":"2020","journal-title":"Ann Hematol"},{"key":"R7-20250805","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1007\/s00277-020-04097-0","article-title":"Autoimmune thrombotic thrombocytopenic purpura (TTP) associated with COVID-19","volume":"99","author":"Albiol","year":"2020","journal-title":"Ann Hematol"},{"key":"R8-20250805","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0002-9343(52)90022-3","article-title":"An acute febrile pleiochromic anemia with hyaline thrombosis of the terminal arterioles and capillaries; 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