{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:25:50Z","timestamp":1787775950644,"version":"build-2784847793"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1]]},"abstract":"\n Background:<\/jats:title>\n \n There are several scolicidal agents for inactivation of hydatid cyst protoscolices during surgery, but most of them are associated with adverse side effects such as sclerosing cholangitis (SC) and liver necrosis. The present study aimed to evaluate the adverse effects of\n Eucalyptus<\/jats:italic>\n essential oil to induce SC in animal models.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Eighteen rabbits weighting 2000\u20133500 g were included in three groups for this study. About 0.3 ml of\n Eucalyptus<\/jats:italic>\n essential oil (1%), or 5% hypertonic saline, or normal saline was injected for 5 min in the gallbladder. After 4 months, the liver, common bile duct, and duodenum were resected and immediately sent for cholangiography and pathologic studies.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n According to pathological studies, inflammation is more common in\n Eucalyptus<\/jats:italic>\n and hypertonic saline groups. Due to cholangiographic studies, stricture was slightly higher in the hypertonic saline group than the\n Eucalyptus<\/jats:italic>\n group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Thus, 1%\n Eucalyptus<\/jats:italic>\n essential oil is at least as safe as 5% hypertonic saline, but for clinical uses, it must be confirmed with further studies.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/abr.abr_210_19","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T07:27:59Z","timestamp":1582874879000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation the Effects of Eucalyptus Essential Oil and Hypertonic Saline as Scolicidal Agents in Induction of Sclerosing Cholangitis in Rabbits"],"prefix":"10.4103","volume":"9","author":[{"given":"Seyed Vahid","family":"Hosseini","sequence":"first","affiliation":[{"name":"From the Colorectal Research Center, Shiraz 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