{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:46:36Z","timestamp":1787071596062,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Cataracts are a leading cause of visual impairment worldwide, necessitating effective non-surgical preventative strategies. This study is the first to evaluate the morphological and histopathological effects of\n                      <jats:italic toggle=\"yes\">Zataria multiflora Boiss<\/jats:italic>\n                      essential oil (ZE) on selenite-induced cataracts in rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Seventy-two male Sprague\u2013Dawley rat pups were randomly assigned to six groups: control (C), vehicle control (VC), ZE control (ZC), selenite (S), selenite plus vehicle (SV), and selenite plus ZE (SE). Cataracts were induced by a single subcutaneous injection of sodium selenite (30 \u03bcmol\/kg) on postnatal day 8. ZE (500 \u03bcL\/kg, diluted 1:1 with olive oil) was administered orally twice weekly for 5 weeks. Cataract severity was graded weekly by using Hiraoka\u2019s scale (0\u20136) by a blinded ophthalmologist. Histopathological changes were qualitatively assessed via hematoxylin and eosin staining. Statistical analysis employed the Kruskal\u2013Wallis test with Dunn\u2019s post-hoc test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      No cataracts developed in the control groups (mean grade: 0). The S and SV groups developed severe cataracts (mean grade: 5.14 \u00b1 0.64). ZE treatment significantly reduced cataract severity in the SE group (mean grade: 2.07 \u00b1 0.59;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05 vs. S and SV). Histopathology showed that ZE preserved lens architecture and markedly reduced degenerative changes compared with S and SV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study provides the first morphological and histological evidence that ZE can prevent or delay cataract formation by preserving lens structure and function in a selenite-induced rat model. ZE demonstrates promising potential as a natural therapeutic agent for cataract prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_219_25","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:00:09Z","timestamp":1759158009000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Protective Effect of Zataria Multiflora Boiss in Selenite-Induced Cataracts: Histopathological and Morphological Evaluation"],"prefix":"10.4103","volume":"14","author":[{"given":"Rasul","family":"Moukhah","sequence":"first","affiliation":[{"name":"Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboobeh","family":"Ashrafi","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, 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