{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:28:26Z","timestamp":1786739306752,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      In this study, researchers evaluated the effects of a plant-based mixture called LCRAC (containing\n                      <jats:italic toggle=\"yes\">Lavandula angustifolia Mill., Syzygium aromaticum (L.) Merr. and L. M. Perry, Rosa damascena Herrm., Astragalus membranaceus (Fisch.) Bunge, and Cornus mas L.<\/jats:italic>\n                      ) on cognition and depression in a rat model of mild cognitive impairment (MCI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Sixty male Wistar rats were randomly assigned to six groups and MCI was induced by intracerebroventricular injection of streptozotocin (STZ). LCRAC (20, 40, or 80 mg\/kg\/day) was administered by gavage for 14 days. Spatial learning and memory, working memory, and avoidance learning were assessed using the Morris water maze (MWM) test, Y-maze continuous alternation task (Y-CAT), and passive avoidance test, respectively. Depressive-like behaviors were examined using the forced swim test (FST). Comprehensive biochemical and histopathological analyses were performed to assess potential toxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>LCRAC treatment significantly improved spatial learning and memory, working memory, and avoidance learning in the STZ-induced MCI rats. LCRAC also exhibited antidepressant-like effects, decreasing immobility time in the FST. Importantly, LCRAC administration did not induce any significant changes in serum biochemical markers or histopathological alterations in the kidney, liver, or hippocampus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The study suggests that LCRAC shows promise as a therapeutic agent for enhancing cognitive function and alleviating depressive-like symptoms in MCI without evident toxicity, warranting further clinical investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_227_24","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:00:50Z","timestamp":1770134450000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A Specific Herbal Mixture of Lavandula, Cloves, Rosa, Astragalus, and Cornus Mas (LCRAC) Improves Cognitive Function in a Rat Model of Streptozotocin-Induced Mild Cognitive Impairment"],"prefix":"10.4103","volume":"14","author":[{"given":"Najmeh","family":"Jamali","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, School of Medicine, Physiology-Pharmacology Research Center, Research Institute on Basic Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayat","family":"Kaeidi","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, School of Medicine, Physiology-Pharmacology Research Center, Research Institute on Basic Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalal","family":"Hassanshahi","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, School of Medicine, Physiology-Pharmacology Research Center, Research Institute on Basic Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad R.","family":"Memarzadeh","sequence":"additional","affiliation":[{"name":"Department of Medicinal Plant Research Center of Barij, Kashan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayebeh","family":"Tavakoli","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, School of Medicine, Physiology-Pharmacology Research Center, Research Institute on Basic Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Taghipour","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Shamsizadeh","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, School of Medicine, Physiology-Pharmacology Research Center, Research Institute on Basic Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11]]},"reference":[{"key":"R1-20260203","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1093\/brain\/awy132","article-title":"The cholinergic system in the pathophysiology and treatment of Alzheimer\u2019s disease","volume":"141","author":"Hampel","year":"2018","journal-title":"Brain"},{"key":"R2-20260203","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ctcp.2018.02.004","article-title":"Comparison of the effect of lavender and bitter orange on anxiety in postmenopausal women: A triple-blind, randomized, controlled clinical trial","volume":"31","author":"Farshbaf-Khalili","year":"2018","journal-title":"Complement Ther Clin Pract"},{"key":"R3-20260203","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neuropharm.2017.09.014","article-title":"Maslinic acid ameliorates NMDA receptor blockade-induced schizophrenia-like behaviors in mice","volume":"126","author":"Jeon","year":"2017","journal-title":"Neuropharmacology"},{"key":"R4-20260203","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1159\/000322340","article-title":"Syzygium cumini extract decrease adenosine deaminase, 5\u2019nucleotidase activities and oxidative damage in platelets of diabetic patients","volume":"26","author":"De Bona","year":"2010","journal-title":"Cell Physiol Biochem"},{"key":"R5-20260203","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1089\/jmf.2016.3660","article-title":"Antistress effects of rosa rugosa thunb. 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