{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:19:24Z","timestamp":1787771964384,"version":"build-2784847793"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Klippel Trenaunay Syndrome (KTS) is an uncommon inherited syndrome identified by venous varicosities and capillary abnormalities. von Willebrand Disease is the most common inherited hemorrhage disturbance in humans, leading to insufficiency in von Willebrand Factor, which is a complex multimeric protein with two functions: it forms a bridge between the platelets and injured vascular areas and it attaches factor VIII and stabilizes it. We present a 13-year-old son with a typical clinical manifestation of KTS, including \u201cport-wine stains\u201d as capillary malformation, venous malformation, and hypertrophy of the left lower extremity, who also suffers from von Willebrand Disease type 3. He has been suffering from these two rare conditions since birth. The occurrence of KTS with von Willebrand Factor deficiency in a patient has so far not been reported, which may propose a mutation in the putative common regulatory gene that caused this uncommon phenotype.<\/jats:p>","DOI":"10.4103\/abr.abr_232_23","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T07:00:24Z","timestamp":1708930824000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["A Rare Case of Klippel Trenaunay Syndrome with Von Willebrand Factor Deficiency and Multiple Accessory Spleens: A Case Report and Brief Literature Review"],"prefix":"10.4103","volume":"13","author":[{"given":"Vahid","family":"Falahati","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Fallahi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Shahriarpour","sequence":"additional","affiliation":[{"name":"Islamic Republic of Iran, Department of Pediatrics, Arak University of Medical Science, Arak, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ghasemi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Hematology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazem","family":"Ghaffari","sequence":"additional","affiliation":[{"name":"Department of Laboratory Sciences, Faculty of Medicine, Khomein University of Medical Sciences, Khomein, 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