{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:32:56Z","timestamp":1787772776752,"version":"build-2784847793"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Rosacea is a multifactorial skin inflammatory disorder with an unknown cure. Genetics and environmental factors such as microorganisms are involved in the rosacea etiology, for example,\n                      <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n                      have been suggested in rosacea progression. The present study investigated the relationship between\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      eradication and rosacea patient's improvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      infection was investigated in 60 rosacea patients and 65 sex- and age-matched healthy control through enzyme-linked immunosorbent assay (ELISA) and HpSag tests. After infection confirmation, randomly half of the rosacea patients were treated for\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      eradication (test), and others received standard treatment (control). HpSag and ELISA tests were repeated after infection eradication and disease flow was surveyed for 60 days. The groups were compared using the ANOVA (Analysis Of Variance) test at the significant level of\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      At the baseline, the mean of immunoglobulin G (IgG) (59.27 \u00b1 41.4 RU\/mL) and immunoglobulin M (IgM) (11.55 \u00b1 6.1 RU\/mL) in rosacea patients was higher than the level of IgG (41.38 \u00b1 54.33 RU\/mL) and IgM (8.11 \u00b1 8.91 RU\/mL) in healthy control (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.04) and (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01), respectively. Also, the values for\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      infection were positive in all patients and 10 healthy controls. The mean titer of IgM and IgG in the test and control patients groups were different at baseline and after treatment. Furthermore, in the test patients group, the mean of IgG was reduced in active rosacea after treatment, and 63.9% of active patients showed rosacea remission after\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      eradication.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Data suggest the exacerbating role of\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      in rosacea, and its eradication along with other therapeutic methods causes rosacea improvement.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_236_22","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T07:04:17Z","timestamp":1688367857000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Association between the Treatment of Rosacea and Eradication of Helicobacter Pylori Infection"],"prefix":"10.4103","volume":"12","author":[{"given":"Maryam","family":"Aghaei","sequence":"first","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrzad","family":"Aghaei","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, 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Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farahnaz F.","family":"Naeini","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Centre, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Iraji","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Centre, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zabihollah","family":"Shahmoradi","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Centre, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed M.","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and 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