{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:32:52Z","timestamp":1787758372442,"version":"build-2784847793"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Toxoplasmosis is a disease caused by\n                      <jats:italic toggle=\"yes\">Toxoplasma gondii,<\/jats:italic>\n                      and one-third of the world's population has\n                      <jats:italic toggle=\"yes\">T. gondii<\/jats:italic>\n                      antibodies. Due to this issue, the aim of this study was to assess the mean prevalence and odds ratios of\n                      <jats:italic toggle=\"yes\">T. gondii<\/jats:italic>\n                      infection and epidemiological features of neonatal infection worldwide.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      We performed a meta-analysis and systematic review of published studies reporting\n                      <jats:italic toggle=\"yes\">T. gondii<\/jats:italic>\n                      infection using the PubMed, MEDLINE, Web of Science, EMBASE, and Scopus electronic databases through January 1999 to December 2020, regarding diagnostic tests, and prevalence data of infection among the newborn population. The pooled prevalence of\n                      <jats:italic toggle=\"yes\">T. gondii<\/jats:italic>\n                      with a 95% confidence interval (CI) was calculated using the random-effects models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of thirty eligible articles were included. The estimated global prevalence rate was 44% (95% CI: 29%\u20130.58%); the highest prevalence rate was in America 47% (95% CI: 30%\u201364%), followed by Europe 41% (95% CI: 26%\u201357%) and Asia 33% (95% CI: 4%\u201361%). In this study, despite our careful analysis of possible modifiers, the heterogeneity was significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.000). The publication bias was not significant based on the results of Egger's (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.918) and Begg's tests (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.230).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Based on the results of this study,\n                      <jats:italic toggle=\"yes\">T. gondii<\/jats:italic>\n                      infection can be a serious concern in newborns around the world. Therefore, further research is needed to provide better strategies to screen and diagnose\n                      <jats:italic toggle=\"yes\">T. gondii<\/jats:italic>\n                      infection in neonates and determine the risk factors associated with the prevalence of infection in neonates worldwide.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_24_21","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T06:23:33Z","timestamp":1664173413000},"page":"75","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Toxoplasmosis Infection in 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