{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:00:41Z","timestamp":1787169641208,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Ectopic pregnancy (EP) occurs in 1% of pregnancies, and may seriously effects on women's health and future fertility so this study aimed to compare the results of hysterosalpingography (HSG) after treatment of EP by laparoscopy, laparotomy, and methotrexate (MTX) therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This was a clinical trial study was done on 112 EP women with treatment indication referred to Isfahan Al-Zahran and Shahid Beheshti Hospitals from 2017 to 2018. They were divided into 33 populated groups of laparoscopic salpingostomy, laparotomy and MTX. Then patients of three groups underwent HSG 3 months after intervention. The factors such beta human chorionic gonadotropin (\u03b2\u2013hCG) (mIU\/mL), size of EP (mm), infection, hospital length of stay (LOS), and tubal patency were recorded and compared between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were no significant differences between groups for age, body mass index, \u03b2\u2013hCG, Size of EP, and hospital LOS (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). The infection was more frequent in laparotomy group with no significant difference among three groups. The infection rates were 9%, 12%, and 6% for MTX, laparotomy, and laparoscopy arms, respectively. Between the three groups tubal patency as primary outcome had higher frequency than laparoscopy group, although, the difference was not statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.595).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although infection was more in laparotomy and that tubal patency was more within 3 months in laparoscopy and MTX, there were no statistically significant differences in the results of laparoscopy, laparotomy, and MTX in HSG results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_258_20","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T02:51:58Z","timestamp":1648608718000},"page":"27","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Comparison the Results of Hysterosalpangiography in Patients with Ectopic Pregnancy Treated by Laparoscopic Salpingostomy, Laparotomy, and Treated with Methotrexate"],"prefix":"10.4103","volume":"11","author":[{"given":"Behnaz","family":"Khani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Ahmadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safoura","family":"Rouholamin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-27-20240830","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s13224-012-0304-z","article-title":"Retrospective study on laparoscopic management of ectopic pregnancy","volume":"63","author":"Chaudhary","year":"2013","journal-title":"J Obstet Gynaecol India"},{"key":"R2-27-20240830","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1136\/sti.76.1.28","article-title":"Epidemiology of ectopic pregnancy during a 28 year period and the role of pelvic inflammatory disease","volume":"76","author":"Kamwendo","year":"2000","journal-title":"Sex Transm Infect"},{"key":"R3-27-20240830","doi-asserted-by":"crossref","first-page":"501","DOI":"10.21608\/ebwhj.2019.45495","article-title":"Single dose Methotrexate injection, could be a safe and effective treatment for early cases of tubal ectopic pregnancy, with minimal maternal health hazards","volume":"9","author":"Soliman","year":"2019","journal-title":"Evid Based Womens Health J"},{"key":"R4-27-20240830","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.5958\/0976-5506.2018.01727.8","article-title":"Tubal patency and pregnancy rate following surgical and medical treatments of ectopic pregnancy","volume":"9","author":"Alkhafajy","year":"2018","journal-title":"Indian J Public Health Res Dev"},{"key":"R5-27-20240830","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/humupd\/dmn012","article-title":"Current evidence on surgery, systemic methotrexate and expectant management in the treatment of tubal ectopic pregnancy: A systematic review and meta-analysis","volume":"14","author":"Mol","year":"2008","journal-title":"Hum Reprod Update"},{"key":"R6-27-20240830","doi-asserted-by":"crossref","first-page":"53.e1","DOI":"10.1016\/j.ajog.2014.07.027","article-title":"A retrospective analysis of the effect of salpingectomy on serum anti Mu\u00a8llerian hormone level and ovarian reserve","volume":"212","author":"Ye","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"R7-27-20240830","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.fertnstert.2013.06.040","article-title":"Effect of single-dose methotrexate on ovarian reserve in women with ectopic pregnancy","volume":"100","author":"Uyar","year":"2013","journal-title":"Fertil Steril"},{"key":"R8-27-20240830","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.fertnstert.2013.08.007","article-title":"Does methotrexate administration for ectopic pregnancy after in vitro fertilization impact ovarian reserve or ovarian responsiveness?","volume":"100","author":"Boots","year":"2013","journal-title":"Fertil Steril"},{"key":"R9-27-20240830","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.fertnstert.2013.10.027","article-title":"Ovarian reserve and subsequent assisted reproduction outcomes after methotrexate therapy for ectopic pregnancy or pregnancy of unknown location","volume":"101","author":"Hill","year":"2014","journal-title":"Fertil Steril"},{"key":"R10-27-20240830","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ejogrb.2014.07.011","article-title":"Evaluation of the effects of single or multiple dose methotrexate administration, salpingectomy on ovarian reserve of rat with the measurement of anti-M\u00fcllerian hormone (AMH) levels and histological analysis","volume":"181","author":"Ulug","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R11-27-20240830","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.jmig.2013.04.005","article-title":"Ovarian response to gonadotropins in patients with tubal factor infertility: Salpingectomy versus nonsalpingectomy","volume":"20","author":"Lin","year":"2013","journal-title":"J Minim Invasive Gynecol"},{"key":"R12-27-20240830","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/humrep\/des375","article-title":"Long-term reproductive outcomes in women whose first pregnancy is ectopic: A national controlled follow-up study","volume":"28","author":"Lund K\u00e5rhus","year":"2013","journal-title":"Hum Reprod"},{"key":"R13-27-20240830","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ejogrb.2016.08.028","article-title":"The impact of salpingectomy and single-dose systemic methotrexate treatments on ovarian reserve in ectopic pregnancy","volume":"205","author":"Sahin","year":"2016","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R14-27-20240830","first-page":"26","article-title":"Comparison of the effect of single and multiple-dose methotrexate therapy on tubal patency in women with ectopic pregnancy","volume":"20","author":"Fakheri","year":"2016","journal-title":"Sci J Kurdistan Univ Med Sci"},{"key":"R16-27-20240830","doi-asserted-by":"crossref","first-page":"e7263","DOI":"10.1097\/MD.0000000000007263","article-title":"Impact of hysterosalpingography after operative treatment for ectopic pregnancy in Taiwan: A 16-year nationwide population-based analysis","volume":"96","author":"Chiu","year":"2017","journal-title":"Medicine (Baltimore"},{"key":"R17-27-20240830","first-page":"400","article-title":"Management of unruptured ectopic gestation by linear salpingostomy: A prospective, randomized clinical trial of laparoscopy versus laparotomy","volume":"73","author":"Vermesh","year":"1989","journal-title":"Obstet Gynecol"},{"key":"R18-27-20240830","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.jmig.2020.10.014","article-title":"A systematic review and meta-analysis of surgical treatment of ectopic pregnancy with salpingectomy versus salpingostomy","volume":"28","author":"Ozcan","year":"2020","journal-title":"J Minim Invasive Gynecol"},{"key":"R19-27-20240830","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0015-0282(16)57289-6","article-title":"Spontaneous resolution of ectopic tubal pregnancy: Natural history","volume":"63","author":"Shalev","year":"1995","journal-title":"Fertil Steril"},{"key":"R20-27-20240830","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0015-0282(97)00414-7","article-title":"Tubal patency and fertility outcome after expectant management of ectopic pregnancy","volume":"68","author":"Rantala","year":"1997","journal-title":"Fertil Steril"},{"key":"R21-27-20240830","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0015-0282(97)81363-5","article-title":"Is hysterosalpingography an important tool in predicting fertility outcome?","volume":"67","author":"Mol","year":"1997","journal-title":"Fertil Steril"}],"container-title":["Advanced Biomedical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/abr.abr_258_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:11:22Z","timestamp":1787166682000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/abr.abr_258_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/abr.abr_258_20","relation":{},"ISSN":["2277-9175"],"issn-type":[{"value":"2277-9175","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}