{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:12:48Z","timestamp":1789848768657,"version":"4.0.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Marine organisms produce a variety of compounds with pharmacological activities including anticancer effects. This study attempt to find cytotoxicity of hexane (HEX), dichloromethane (DCM), and butanol (BUTOH) partitions of\n                      <jats:italic toggle=\"yes\">Sargassum angustifolium<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">S. angustifolium<\/jats:italic>\n                      was collected from Bushehr, a Southwest coastline of Persian Gulf. The plant was extracted by maceration with methanol-ethyl acetate. The extract was evaporated under vacuum and partitioned by Kupchan method to yield HEX, DCM, and BUTOH partitions. The cytotoxic activity of the extract (150, 450, and 900 \u03bcg\/ml) was investigated against MCF-7 (breast cancer), HeLa (cervical cancer), and human umbilical vein endothelial cells cell lines by mitochondrial tetrazolium test assay after 72 h.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The cell survivals of HeLa and MCF-7 cell were decreased by increasing the concentration of extracts from 150 \u03bcg\/ml to 900 \u03bcg\/ml. The median growth inhibitory concentration value of HEX partition was 71 and 77 \u03bcg\/ml against HeLa and MCF-7, dichloromethane partition was 36 and 88 \u03bcg\/ml against HeLa and MCF-7, respectively. BUTOH partition was 25 \u03bcg\/ml against MCF-7.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      This study reveals that different partitions of\n                      <jats:italic toggle=\"yes\">S. angustifolium<\/jats:italic>\n                      have cytotoxic activity against cancer cell lines.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_259_16","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T00:42:07Z","timestamp":1522111327000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Cytotoxicity of Sargassum angustifolium Partitions against Breast and Cervical Cancer Cell Lines"],"prefix":"10.4103","volume":"7","author":[{"given":"Golnaz","family":"Vaseghi","sequence":"first","affiliation":[{"name":"From the Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Sharifi","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Isfahan Pharmaceutical Research Centre, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Dana","sequence":"additional","affiliation":[{"name":"Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Ghasemi","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsaneh","family":"Yegdaneh","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Isfahan Pharmaceutical Research Centre, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,3,27]]},"reference":[{"key":"R1-20251008","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1007\/s13197-010-0165-3","article-title":"Studies on development and storage stability of instant spice adjunct mix from seaweed (Eucheuma)","volume":"48","author":"Senthil","year":"2011","journal-title":"J Food Sci Technol"},{"key":"R2-20251008","first-page":"35","article-title":"Biological interactions during the life history of seaweed \u2013 A microscopic review","volume":"2","author":"Mine","year":"2008","journal-title":"Kuroshio Science"},{"key":"R3-20251008","first-page":"119","article-title":"Evaluation of antioxidant and antimicrobial activity of seaweed (Sargassum sp.) extract: A study on inhibition of glutathione-S-transferase activity","volume":"32","author":"Patra","year":"2008","journal-title":"Turk J Biol"},{"key":"R4-20251008","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s11745-007-3035-7","article-title":"Two new monogalactosyl diacylglycerols from brown alga Sargassum thunbergii","volume":"42","author":"Kim","year":"2007","journal-title":"Lipids"},{"key":"R5-20251008","doi-asserted-by":"crossref","first-page":"311","DOI":"10.4103\/1735-5362.189307","article-title":"Chemical constituents and biological activities of two Iranian Cystoseira species","volume":"11","author":"Yegdaneh","year":"2016","journal-title":"Res Pharm Sci"},{"key":"R6-20251008","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s12010-011-9178-2","article-title":"Fucoidans from brown seaweeds Sargassum hornery, Eclonia cava, Costaria costata: Structural characteristics and anticancer activity","volume":"164","author":"Ermakova","year":"2011","journal-title":"Appl Biochem Biotechnol"},{"key":"R7-20251008","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1139\/o02-169","article-title":"Isolation and characterization of a sulfated polysaccharide from the brown alga Sargassum patens and determination of its anti-herpes activity","volume":"81","author":"Zhu","year":"2003","journal-title":"Biochem Cell Biol"},{"key":"R8-20251008","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1248\/bpb.21.730","article-title":"An antivirally active sulfated polysaccharide from Sargassum horneri (TURNER) C. 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