{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T11:03:36Z","timestamp":1794049416502,"version":"4.8.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n The measurement of androgens (testosterone and dehydroepiandrosterone sulfate (DHEAS)) remains standard for the evaluation of polycystic ovarian syndrome (PCOS) women. However, other early novel androgen markers, 5 alpha-dihydrotestosterone (DHT) and 11-ketotestosterone (11-KT), may open a separate path of measurement, which may be more potent. The study was conducted with the objectives to analyze the association of 11-KT and DHT with established markers and with the clinical profile of PCOS patients.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n A case\u2013control study was conducted on 30 newly diagnosed cases of PCOS as per the Rotterdam criteria and 30 age-matched controls. The estimation of testosterone, DHEAS, 11-KT, and DHT was performed by the enzyme-linked immunoassay (ELISA) method. The assessment of biochemical and hormonal parameters was compared and correlated with 11-KT and DHT.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Compared to the controls, cases had significantly higher 11-KT (20.81 \u00b1 3.53 vs. 15.83 \u00b1 2.67 nmol\/L,\n P<\/jats:italic>\n < 0.0001) and DHT (154.39 vs. 71.02 pg\/mL,\n P<\/jats:italic>\n < 0.0001). 11-KT showed a significant positive correlation with total testosterone (TT) (r = 0.555) and DHEAS (r = 0.501). DHT also showed a significant positive correlation with TT (r = 0.487) and DHEAS (r = 0.52).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n In conclusion, novel androgen derivatives (11-KT and DHT) hold equivalent evidence for the evaluation of women with PCOS as they are raised in women with PCOS as compared to controls. Moreover, they show a good correlation with the standard markers currently used for PCOS.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/abr.abr_262_23","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T07:00:25Z","timestamp":1738220425000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["A Case\u2013Control Study of the Association of Novel Androgens (11-KT and DHT), Classical Androgens (Testosterone and DHEAS), Hormones (LH, FSH, 17-OHP, Insulin, and SHBG), Insulin Resistance (HOMA-IR), and Dyslipidemia in Polycystic Ovarian Syndrome (PCOS)"],"prefix":"10.4103","volume":"14","author":[{"given":"Nirmal","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Biochemistry, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neera","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indu","family":"Chawla","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lokesh Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1]]},"reference":[{"key":"R1-20250130","first-page":"89.","article-title":"The mechanism of androgen actions in PCOS etiology","volume":"7","author":"Rodriguez Paris","year":"2019","journal-title":"Med Sci (Basel)"},{"key":"R2-20250130","doi-asserted-by":"crossref","first-page":"16057.","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic ovary syndrome","volume":"2","author":"Azziz","year":"2016","journal-title":"Nat Rev Dis Prim"},{"key":"R3-20250130","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/humupd\/dmy022","article-title":"Understanding variation in prevalence estimates of polycystic ovary syndrome: A systematic review and meta-analysis","volume":"24","author":"Skiba","year":"2018","journal-title":"Hum Reprod Update"},{"key":"R4-20250130","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1093\/humrep\/dey256","article-title":"International PCOS Network. 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