{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:22:45Z","timestamp":1787757765425,"version":"build-2784847793"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Oral candidiasis (OC) has been noticed as a common mucous membrane infection in immunocompromised patients such as that diabetes. This study, focused on the genotyping of\n                      <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                      and enzymatic activities of\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      species recovered from oral mucosa among diabetes patients and healthy individuals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Specimens were obtained from oral mucosa of One-hundred and sixty patients with type 2 diabetic and 108 healthy individuals. All isolates were definitely identified by ribosomal DNA (rDNA) gene sequencinghHydrophobicity, hemolytic activities of\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      species and genotypes of C. albicans were determined through polymerase chain reaction (CA-INT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      , Eighty eight (55%) samples out of 160, were positive for\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      species in diabetic patients. Moreover, 79.5% (70\/88) and 20.5% (18\/88) isolates belonged to the\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      and non-\n                      <jats:italic toggle=\"yes\">albicans Candida<\/jats:italic>\n                      species respectively. Three genotypes of\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      have recovered in diabetic patients: genotype A (71.42%), B (21.42%), and C (7.14%). In healthy individuals, 42.6% (46\/102)\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      species recovered from oral cavity, with the highest prevalence of genotype A (76.6% of\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      ). Additionally, hydrophobicity and hemolytic activities from\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      species were significantly greater in diabetes patients than healthy nondiabetic subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Collectively,\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      was the most causative agent isolated from diabetes patients and non-diabetes healthy individuals. Genotype A, as the most remarkable genotype, should be mentioned in both groups. Higher potential hydrophobicity and hemolytic activities of\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      species in diabetic patients compared to healthy cases suggest these features triggering pathogenicity of OC in diabetes patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_26_21","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T02:54:15Z","timestamp":1651200855000},"page":"29","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Prevalence, Molecular Identification, and Genotyping of Candida Species Recovered from Oral Cavity among Patients with Diabetes Mellitus from Tehran, 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